DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and ppw-1

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_491323.2	Gene:	ppw-1 / 172013	WormBaseID:	WBGene00004093	Length:	887	Species:	Caenorhabditis elegans

Alignment Length:	898	Identity:	186/898 - (20%)
Similarity:	329/898 - (36%)	Gaps:	248/898 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 REGGPTERKPWGDQYDYLNTRPAELVSKKGTD---GVPVMLQTNFFRLKTKPEWRIVHYHVEF-- 121
            |...|..:|        |.|.|  |.:||..:   |..|.:.||..:|..||...|..|.|:.
Worm    13 RPAAPAAQK--------LGTAP--LAAKKTRNVERGTKVNIDTNIRKLTIKPNQPIYKYAVQVNY 67

  Fly   122 --------EPSIE------------NPRVRMGVLSNHA-----NLLGSGYLFDGLQ--LFTTRKF 159
                    |.:||            |.:.|...:.|.|     .|...|..|...|  |:|..|.
Worm    68 VFRKPDGTEATIEMSKSAKKGTEHDNDKTRCQKVYNEAIKRYDELKTGGPFFYDRQASLYTLTKL 132

  Fly   160 EQEIT--VLSGK--------------SKLDIEYKIS----IKFVGFISC---AEPRFLQVLNLIL 201
            :.|..  |::.|              .|:|..::.:    |:...  ||   |:...|:.:|:|:
Worm   133 KNESISFVVTDKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTN--SCPANADKTLLEAMNIIV 195

  Fly   202 R-RSMKGLNLELVG---RNLFDPR-AKIEIREF-KMELWPGYETSIRQHEKDI--LLGTE--ITH 256
            . .:.:..|:..||   ..|.||. ..:..:|: :.:|:.|...|     |.:  |.||:  :..
Worm   196 SGPAFENKNVITVGACVHYLIDPTVVDVAYKEYAEGQLYSGVGAS-----KSVKTLEGTDKKVPS 255

  Fly   257 KVMRTE---TIY--------DIMRRC--------SHNPARHQDEVRVNVLDLIVLTDYN------ 296
            ..|.||   |::        ::::..        :::||..:.|.....||:::  :|.
Worm   256 LFMTTEMKTTLFHPDYAPLVELLQTFRGFSTTLKANSPAAQRIEKAFVGLDVVL--NYGVHKGLG 318

  Fly   297 --------NRTYRINDVDFGQTPKSTFSCKGRDISFV-EYYLTKYNIRIRDHNQPLLISKNRDKA 352
                    .|.:........:..|||     |:.:.| :|:..||.|.::..:...:.:|.:...
Worm   319 EDGVVMKIRRFHTSAKETCFEVEKST-----REFTNVFDYFKKKYGITLKYPDLFTIEAKGKQGK 378

  Fly   353 LKTNASELVVLIPELCRVTGLNAEMRSNFQL----MRAMSSYTRMNPKQRTDRL-RAFNHRLQNT 412
            :...| |:::|.|   ..|..|.:|.:|.|.    |.|...:.|   |..||.: |.......|.
Worm   379 IHFPA-EVLLLCP---NQTVTNDQMINNEQADMIKMSAAQPHIR---KTTTDTIVRNVGLASNNI 436

  Fly   413 PESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGEN------ADWQR--HFRDQRMLT 469
            ...:||....|:|         |.::.:..|.|...::....|      .|:.|  .:.|.:.||
Worm   437 YGFIKVEDPVNLE---------GMVLPKPKIAFAGNQLADLANPKSRFPTDFNRAGQYYDAKELT 492

  Fly   470 TPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRSP-QEFIIYDDRTGTYVRAMDDCVR 533
                   :|.::..|  :.|::.|...|.......|::..:| ..|||..|....:.:|     :
Worm   493 -------KWELVFVQ--NEEVQGLAKQLADEMVNNGMKCSNPTMSFIIRGDLEPIFKKA-----K 543

  Fly   534 SDPKLILCLVPNDNAERYSSIK--KRGYVDRAVPTQVVTLKTTKN-----RSLMSIATKIAIQLN 591
            :....:|..|.......:..||  ::.|   .|.||.:..:|.:.     ::.::|..|    .|
Worm   544 AAGTQLLFFVVKSRYNYHQQIKALEQKY---DVLTQEIRAETAEKVFRQPQTRLNIINK----TN 601

  Fly   592 CKLGYTPWMI-------------------------ELPLSGLMTIGFDIAKSTRDRKRAYGALIA 631
            .|||...:.|                         :.|:|    :||........:|.|.|.:..
Worm   602 MKLGGLNYAIGSEAFNKPNRLIVGFVTSQRVGGNPDYPIS----VGFAANMLKHHQKFAGGYVYV 662

  Fly   632 SMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQL- 695
            ..|    ...|.:        ::.:||     .|:.:...|.|..|..|:.|.:|||.|....:
Worm   663 HRD----RDVFGS--------IIKDTL-----LAIFKTCTEQRGRPDDILLYFNGVSEGQFSMIN 710

  Fly   696 --FEFEVKDIIEKLKTEYARVQLSP---PQLAYIVVTRSMNTRFFLNGQ----NPPPGTIVDDVI 751
              |...||:.....:.|.     :|   |.:..|..:::.|.|.:.:.:    |..|||:||..|
Worm   711 EEFSARVKEACMAFQKEG-----TPPFRPHITIIASSKAHNERLYKSDKGRIVNLEPGTVVDHTI 770

  Fly   752 TLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPE-----KMQKLTYKMCH 799
            ......::|..|...||||...|.:.:::::.. .|:     .:::||..:|:
Worm   771 VSNVYTEWYHASAVARQGTAKATKFTLIFTTKA-GPQAEPLWHLEQLTNDLCY 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	35/164 (21%)
		PAZ	262..396	CDD:198017	31/171 (18%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	98/479 (20%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	19/124 (15%)
ppw-1	NP_491323.2	Piwi-like	444..849	CDD:239208	87/436 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920