DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and PIWIL4

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_689644.2	Gene:	PIWIL4 / 143689	HGNCID:	18444	Length:	852	Species:	Homo sapiens

Alignment Length:	878	Identity:	294/878 - (33%)
Similarity:	453/878 - (51%)	Gaps:	79/878 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADDQGRGRRRPL--------NEDDSS-----TSR---------GSGDGPRVKVFRGSSSGDPRAD 44
            |.:.||.:..||        ||..||     |||         .|||.....:.||..:.....|
Human    18 ATEVGRIQASPLPRSVDLSNNEASSSNGFLGTSRISTNDKYGISSGDAGSTFMERGVKNKQDFMD 82

  Fly    45 PRIEASRERRALEEAPRREGGPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTK 109
            ..| .:||:.|                        :.|..    |.|:.|:||.|.||.|.|...
Human    83 LSI-CTREKLA------------------------HVRNC----KTGSSGIPVKLVTNLFNLDFP 118

  Fly   110 PEWRIVHYHVEFEPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDI 174
            .:|::..|||.:.|.:.:.|:|:.:|.:|:.|......|||..||.::|.|:::|.||.:::...
Human   119 QDWQLYQYHVTYIPDLASRRLRIALLYSHSELSNKAKAFDGAILFLSQKLEEKVTELSSETQRGE 183

  Fly   175 EYKISIKFVGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYET 239
            ..|::|.....:..:.|..:||.|:|.|:.:|.|::..:|||.::|...:||.:.|:.||||:..
Human   184 TIKMTITLKRELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHKLSLWPGFAI 248

  Fly   240 SIRQHEKDILLGTEITHKVMRTETIYDIMR--------RCSHNPARHQDEVRVNVLDLIVLTDYN 296
            |:...|:.:|...::::||:|.||:.:.|.        .|.......|      ::.|||||.||
Human   249 SVSYFERKLLFSADVSYKVLRNETVLEFMTALCQRTGLSCFTQTCEKQ------LIGLIVLTRYN 307

  Fly   297 NRTYRINDVDFGQTPKSTFSCK-GRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASEL 360
            ||||.|:|:|:...|..||..: |.:|::|:||..:|:|.:.|.|||:|:|..:.|....:.::|
Human   308 NRTYSIDDIDWSVKPTHTFQKRDGTEITYVDYYKQQYDITVSDLNQPMLVSLLKKKRNDNSEAQL 372

  Fly   361 VVLIPELCRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNME 425
            ..||||||.:|||..:..|:||||:|::..||::|..|..||......:|....:...|..|.:.
Human   373 AHLIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRLARLVDNIQRNTNARFELETWGLH 437

  Fly   426 LDKNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHEL 490
            ....:: :.|||:..:.|:..:........|||.:..|..::|...|  |:.|.::...|..:..
Human   438 FGSQIS-LTGRIVPSEKILMQDHICQPVSAADWSKDIRTCKILNAQS--LNTWLILCSDRTEYVA 499

  Fly   491 RTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIK 555
            .:.|:.|.|.|..||..:..| :.|...:....:|||:...|..|.:|::|::|::....|.|||
Human   500 ESFLNCLRRVAGSMGFNVDYP-KIIKVQENPAAFVRAIQQYVDPDVQLVMCILPSNQKTYYDSIK 563

  Fly   556 KRGYVDRAVPTQVVTLKT-TKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKST 619
            |....|..||:|.|..:| .|...:||||||||:|:.||||...|.:|:||..||.:|.|:.|..
Human   564 KYLSSDCPVPSQCVLARTLNKQGMMMSIATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDVCKDA 628

  Fly   620 RDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYR 684
            ..:.......:||::.:....:...:.:.:..|| |:.|...:..||.::...:..||:||:.||
Human   629 LSKDVMVVGCVASVNPRITRWFSRCILQRTMTDV-ADCLKVFMTGALNKWYKYNHDLPARIIVYR 692

  Fly   685 DGVSSGSLKQLFEFEVKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFF--LNG--QNPPPGT 745
            .||..|.||.|.|:||..::..:....:.   :..:|:.|||.:....|||  :|.  ||||.||
Human   693 AGVGDGQLKTLIEYEVPQLLSSVAESSSN---TSSRLSVIVVRKKCMPRFFTEMNRTVQNPPLGT 754

  Fly   746 IVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRV 810
            :||...|..|.|||||:||...:||||||.|||:|...||.|:.||:||:|:|||||||.|...|
Human   755 VVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHLYYNWPGIVSV 819

  Fly   811 PAVCQYAKKLATLVGTNLHSIPQNALEKKFYYL 843
            ||.||||.||..||..::|..|...|....:||
Human   820 PAPCQYAHKLTFLVAQSIHKEPSLELANHLFYL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	35/109 (32%)
		PAZ	262..396	CDD:198017	54/142 (38%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	161/448 (36%)
PIWIL4	NP_689644.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		9/29 (31%)
		PAZ_piwi_like	270..386	CDD:239211	45/121 (37%)
		Piwi_piwi-like_Euk	394..835	CDD:240016	161/448 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147169
Domainoid	1	1.000	131	1.000	Domainoid score	I5169
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.720