DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and piwil4

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_012813692.2	Gene:	piwil4 / 100486962	XenbaseID:	XB-GENE-993661	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	868	Identity:	299/868 - (34%)
Similarity:	455/868 - (52%)	Gaps:	63/868 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DDQGRGRRRPLNEDDSSTSR-----GSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRR 62
            |..|:..:......|:.:|:     |||:|          ||.......|.|...|..|.|...|
Frog    22 DSPGQASKMSNPRPDAGSSKDLQGIGSGNG----------SGRDSGIGTISAGENRYVLAERGGR 76

  Fly    63 EG------GPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEF 121
            .|      |...|:......|:          |.||.|.||.|.||.|.|....:|::..|.|:|
Frog    77 NGRNLQDFGINTRQTMAHVKDH----------KTGTSGAPVKLMTNLFGLTLPTQWKLYQYRVDF 131

  Fly   122 EPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQ----EITVLSGKSKLDIEYKISIKF 182
            .|...:.:::..:|.:|...||....|.|..||.:|...:    |.|...|::     .||:|..
Frog   132 SPEFASRKLKTALLYSHGETLGRARAFHGEILFLSRNIGKLNHLESTTRKGET-----VKITITL 191

  Fly   183 VGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKD 247
            ...:....|..:|...::.::..|.||:..||||.::|...:.|.:.::.||||:..||.:.|..
Frog   192 TNQLPADSPVCIQFFGILFKKVFKSLNMYQVGRNYYNPADPVIIPQHRLMLWPGFVLSIMKLESQ 256

  Fly   248 ILLGTEITHKVMRTETIYDIMRRC-SHNP-ARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQT 310
            :.|..:::|||:|.||:.|.|:.. |..| .|..|.....:|.|:|||.|||:|||::|:|:...
Frog   257 LALCADVSHKVLRNETVLDSMKALYSKVPKERFTDICEKELLGLVVLTRYNNKTYRVDDIDWSTK 321

  Fly   311 PKSTFSCK-GRDISFVEYYLTKYNIRIRDHNQPLLISK-NRDKALKTNASELVVLIPELCRVTGL 373
            |..:|..| |.:|::.:||..:|:|.|.|..||:|:|. ...|:...:|...|.||||||.:|||
Frog   322 PTDSFPRKDGSEITYTDYYSQQYSINISDLQQPMLVSTLKAKKSDNPDAPRAVHLIPELCYLTGL 386

  Fly   374 NAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRII 438
            ::...|:|:||:.:|..|:::|::|..||:.....:|.|||:...|..|.:.:||.: .|.|||.
Frog   387 SSRALSDFRLMKDLSMETQLDPERRQQRLQRLADSIQRTPEASAELEKWGLRMDKQI-PVTGRIA 450

  Fly   439 GQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASG 503
            ..:.|...:.....|..|||.|..|:::::....  |..|.::...||:.....||..|.:.|||
Frog   451 PPERIFMRDNVCTPGSPADWARDTRNEKVICVAP--LQNWLMLFSYRNADVAENLLQCLMKVASG 513

  Fly   504 MGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQV 568
            ||..:..|: .:..:|...:::|.:...|..|.:|:.|::|.:..:.|.||||...:|:.||:|.
Frog   514 MGFHMDMPR-IVQVEDNPVSFLRTLQKNVTPDLQLVFCVIPTNQKDSYDSIKKFLSLDQPVPSQC 577

  Fly   569 VTLKTT-KNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIAS 632
            |..:|. :.:.:||:|.|||:|:.||||...|.:|:||..||.:|.||.|...::..:....:||
Frog   578 VQNRTLGRQQMMMSVANKIAMQMICKLGGELWAVEIPLKALMVVGIDINKDAVNKSMSVVGFVAS 642

  Fly   633 MDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFE 697
            .:.:....:...:.:.:..| .|:.|...:..|::.:|..:..||:|||.|||||..|.||.:.:
Frog   643 TNARLTRWHSRCIIQKTTSD-FADCLKMCMKGAIQNWQRCNNDLPNRIVVYRDGVGDGQLKMVVD 706

  Fly   698 FEVKDII---EKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNG----QNPPPGTIVDDVITLPE 755
            :|:..::   .:.||.|.      |:|:.|||.:...:||:...    |||..|||||...|.||
Frog   707 YEIPQLLSSFRETKTSYC------PRLSVIVVRKKCISRFYTQTGRGIQNPVLGTIVDSEATRPE 765

  Fly   756 RYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKL 820
            .|||||:||..|||||:||.||||....||.|:.||:||||:|||||||.|..||||.||||.||
Frog   766 WYDFYLISQNARQGTVNPTYYNVLLDENGLKPDHMQRLTYKLCHLYYNWPGVIRVPAPCQYAHKL 830

  Fly   821 ATLVGTNLHSIPQNALEKKFYYL 843
            ..|||.::|..|...|..|.:||
Frog   831 TFLVGQSIHREPSPELSHKLFYL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	32/113 (28%)
		PAZ	262..396	CDD:198017	54/137 (39%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	168/451 (37%)
piwil4	XP_012813692.2	ArgoL1	221..267	CDD:400854	15/45 (33%)
		PAZ	271..409	CDD:198017	54/137 (39%)
		Piwi_piwi-like_Euk	395..836	CDD:240016	168/451 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030