DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCAR and WASF1

DIOPT Version :9

Sequence 1:	NP_001260368.1	Gene:	SCAR / 34519	FlyBaseID:	FBgn0041781	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001020105.1	Gene:	WASF1 / 8936	HGNCID:	12732	Length:	559	Species:	Homo sapiens

Alignment Length:	742	Identity:	227/742 - (30%)
Similarity:	311/742 - (41%)	Gaps:	257/742 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIG 65
            |||.||:|:|.|:..:...:....  |||.|||.:|.|||||||||||:|||:||||..:..:..
Human     1 MPLVKRNIDPRHLCHTALPRGIKN--ELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFS 63

  Fly    66 DRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQC 130
            .|.||||.|:|||::.|||||...||:.|.|||.:|||:|:.:.|||:|.|.|:|.|:.:||..|
Human    64 FRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVC 128

  Fly   131 DKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAA 195
            ::||||:.|..||||||:||||||:|:|||:||:::||:|||    ||.|:..:.:|..     .
Human   129 EQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTE----DKRKEKRKQKQKN-----L 184

  Fly   196 GRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGIQLVKIQTVGEA 260
            .|.::.:|.. |.||:.|.:.::  |..|..|                              .|.
Human   185 DRPHEPEKVP-RAPHDRRREWQK--LAQGPEL------------------------------AED 216

  Fly   261 DIDLRHSTLDAHHQVVGNIQDVDTVKPYNMLSHLENNSNVTKQTAVAIADMGVYDTRPPRPNSIE 325
            |.:|.|                         .|:|          ||......::|||
Human   217 DANLLH-------------------------KHIE----------VANGPASHFETRP------- 239

  Fly   326 LNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQMYDAGMYQSHAL-YGQTGQ 389
                                                  |.::.|..    |.|...|| :.|..:
Human   240 --------------------------------------QTYVDHMD----GSYSLSALPFSQMSE 262

  Fly   390 GVMSPEPIYGPGTPSRNKPRPSQPPPAPPSNGSGGGTPTASNANTPT-----RGRSMSTSRDAL- 448
            .:...|        .|...||.:|||.||.:|:|...|..:..::.|     |.:|.:|.|..:
Human   263 LLTRAE--------ERVLVRPHEPPPPPPMHGAGDAKPIPTCISSATGLIENRPQSPATGRTPVF 319

  Fly   449 ------PPPPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNTF 507
                  |||||:|..:|..|                 ..:|..:..|..|........|.|.
Human   320 VSPTPPPPPPPLPSALSTSS-----------------LRASMTSTPPPPVPPPPPPPATALQ--- 364

  Fly   508 HSIGMTGNQLNSLSDLPPPPPVPDQHSP---------------KMSPP--NAAP----------- 544
                         :...||||.|.|.:|               :.|||  .|||
Human   365 -------------APAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLP 416

  Fly   545 -------PPPPPPPPVEEGMGSGNQHTLRPHQILPKS------LA---NGEMQQPGQQNGVPHI- 592
                   ||||||||            |.|..|.|.|      ||   :|....|....| ||:
Human   417 QGEVQGLPPPPPPPP------------LPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPG-PHVP 468

  Fly   593 -------------VAPKK---MLPPFHDPRNDLMKAIRDGITLRKVEKSEQKEIERNAAPLDVAS 641
                         ..||:   .||...|.|:.|::|||.||.|||||:..::|.:......|||:
Human   469 LMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVAT 533

  Fly   642 ILARRVAIELSESEDSDSEDDSEGWME 668
            ||:||:|:|.|:||| |||.|...|:|
Human   534 ILSRRIAVEYSDSED-DSEFDEVDWLE 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAR	NP_001260368.1	None
WASF1	NP_001020105.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..202		10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..400		26/128 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..491		22/91 (24%)
		WH2_WAVE-1	485..559	CDD:409214	35/74 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159894
Domainoid	1	1.000	248	1.000	Domainoid score	I2143
eggNOG	1	0.900	-	-		E1_KOG1830
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2641
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54445
OrthoDB	1	1.010	-	-		D1183697at2759
OrthoFinder	1	1.000	-	-		FOG0000853
OrthoInspector	1	1.000	-	-		otm42006
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4420
SonicParanoid	1	1.000	-	-		X835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940