Protein Alignment SCAR and wasf3

DIOPT Version :10

• Sequence 1: NP_001260368.1
• Gene: SCAR / 34519
• FlyBaseID: FBgn0041781
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_001072263.1
• Gene: wasf3 / 779716
• XenbaseID: XB-GENE-1013965
• Length: 502
• Species: Xenopus tropicalis
• Alignment Length: 683
• Identity: 226/683 - (33%)
• Similarity: 305/683 - (44%)
• Gaps: 196/683 - (28%)

  Fly     1 MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIG 65
            |||.||:|||.|:.|... .|.:.| |||.|||:||..||||||||||||||:||||..:..|..
 Frog     1 MPLVKRNIEPRHLCRGTL-PDGITS-ELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFY 63

  Fly    66 DRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQC 130
            .||||||.||||||:||||||||||||.|.||..:|||||:...|||:.|:.::|.|::|.|..|
 Frog    64 IRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMRKAFKSSTTQDQQVVSKNSIPKPVIDIYRTC 128

  Fly   131 DKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAA 195
            |:|||||.|:.||||.||.|||||||:|||:||:::||:|||....:|.::..:.|.|
 Frog   129 DRPPPLDILSAYRDDKKDSLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRVD------- 186

  Fly   196 GRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGIQLVKIQTVGEA 260
              |..::..|:|...|.|  |....:.:.:.|.|:|.:  :||..
 Frog   187 --GTTREVKKVRKARNRR--QEWNIMAYDKELRPDNRL--SPNVF-------------------- 225

  Fly   261 DIDLRHSTLDAHHQVVGNIQDVDTVKPYNMLSHLENNSNVTKQTAVAIADMGVYDTRPPRPN-SI 324
                         ||.                  .:..:::..|...|:|:..| :.|..|| ||
 Frog   226 -------------QVA------------------SSEGSLSPDTRSHISDITEY-SYPATPNHSI 258

  Fly   325 ELNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQMYDAGMYQSHALYGQTGQ 389
            .             .:...|..||:.          .||. |:...|..|.. |:|.:  |....
 Frog   259 H-------------HHPMTPTYMGSV----------DPQH-HIGTSQTNDHD-YRSAS--GTLRH 296

  Fly   390 GVMSPEPIYGPGTPSRNKPRPSQPPPAPPSNGSGGGTPTASNANTPTRGRSMSTSRDALPP---- 450
            |.:|               ||.||||.||:...|.......:||        .:.|..|||
 Frog   297 GTLS---------------RPQQPPPPPPAGVDGTSPVPIVSAN--------GSLRRVLPPQMME 338

  Fly   451 ------PPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNTFHS 509
                  |||.|.||.                               |.|.|      .:|...||
 Frog   339 YYPTGSPPPPPPVIP-------------------------------SAQTA------FVSPLQHS 366

  Fly   510 I-GMTGNQLNSLSDLPPPPP---VPDQHSPKMSPPNAAPPPPPPPPPVEEGMGSGNQHTLRPHQI 570
            : .....|::..:..|.|||   :....||      ..|||||.||...:.:.|...|..|   :
 Frog   367 LPSSPAAQMSGSTYAPSPPPGGIINLLASP------GPPPPPPGPPAFAQSLASSPMHFAR---V 422

  Fly   571 LPKSLANGEMQQPGQQNGVPHIVAPKKMLPPFHDPRNDLMKAIRDGITLRKVEKSEQKEIERNAA 635
            |.....:|                 .::|....|.|:||:.|||.||.|:||::..::|.:|...
 Frog   423 LEAKRLDG-----------------AQLLGLTSDARSDLLSAIRMGIQLKKVQEQREQEAKREPV 470

  Fly   636 PLDVASILARRVAIELSESEDSDSEDDSEGWME 668
            ..|||:||:||:|:|.|:||| :||.|...|.:
 Frog   471 GNDVATILSRRIAVEYSDSED-ESEFDENDWSD 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAR	NP_001260368.1	WH2	599..>650	CDD:425359	23/50 (46%)
wasf3	NP_001072263.1	WH2_WAVE-3	437..502	CDD:409216	31/65 (48%)
		actin-binding sequence	454..457	CDD:409216	1/2 (50%)