Protein Alignment SCAR and WASF3

DIOPT Version :9

• Sequence 1: NP_001260368.1
• Gene: SCAR / 34519
• FlyBaseID: FBgn0041781
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_006637.2
• Gene: WASF3 / 10810
• HGNCID: 12734
• Length: 502
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 231/691 - (33%)
• Similarity: 300/691 - (43%)
• Gaps: 212/691 - (30%)

  Fly     1 MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIG 65
            |||.||:|||.|:.|...  .|..:.|||.|||:||..||||||||||||||:||||..:..|..
Human     1 MPLVKRNIEPRHLCRGAL--PEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFY 63

  Fly    66 DRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQC 130
            .||||||.||||||:||||||||||||.|.||..||||||:.|.|||:.|:.::|.|:.|.|.|.
Human    64 IRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNQS 128

  Fly   131 DKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAA 195
            ||||||:.|..||||.||||||||||:|||:||:::||:|||....:|.::..:.|.|
Human   129 DKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRID------- 186

  Fly   196 GRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGIQLVKIQTVGEA 260
              |..::..|:|...|.|::....|  :.:.|.|:|   |...|:.:..:..|
Human   187 --GTTREVKKVRKARNRRQEWNMMA--YDKELRPDN---RLSQSVYHGASSEG------------ 232

  Fly   261 DIDLRHSTLDAHHQVVGNIQDVDTVKPYNMLSHLENNSNVTKQTAVAIADMGVYDTRPPRPNSIE 325
                                   ::.|                           ||
Human   233 -----------------------SLSP---------------------------DT--------- 238

  Fly   326 LNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQ----MYDAGMYQSHALYGQ 386
              ||:.|:..|.|            |.||       |.  |..|.|    .|.||....|....|
Human   239 --RSHASDVTDYS------------YPAT-------PN--HSLHPQPVTPSYAAGDVPPHGPASQ 280

  Fly   387 TGQGVMSPEPIYGPGTPSRNKP--RPSQPPPAPPSNGSGGGTPTASNANTPTR--------GRSM 441
            ..:....|     |...:|:..  ||.||||.||..     .|..|.|:.|..        .:.:
Human   281 AAEHEYRP-----PSASARHMALNRPQQPPPPPPPQ-----APEGSQASAPMAPADYGMLPAQII 335

  Fly   442 STSRDALPPPPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNT 506
            .....:.|||||.|.||.                               |.|.|
Human   336 EYYNPSGPPPPPPPPVIP-------------------------------SAQTA----------- 358

  Fly   507 FHSIGMTGNQLNSLSDLPPPPPVP----DQHSPKMSPPN-----AAPPPPPPPPPVEEGMGSGNQ 562
                      ..|...:|..||.|    ..|:....||:     .|||||.||||.....|.|:.
Human   359 ----------FVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSS 413

  Fly   563 HTLRPHQILPKSLANGEMQQPGQQNGVPHIVAPKKMLPPFHDPRNDLMKAIRDGITLRKVEKSEQ 627
            .:..|....|  :|..:.|:|.|              ||..|.|:||:.|||.||.|:||::..:
Human   414 LSSSPMHGPP--VAEAKRQEPAQ--------------PPISDARSDLLAAIRMGIQLKKVQEQRE 462

  Fly   628 KEIERNAAPLDVASILARRVAIELSESEDSDSEDDSEGWME 668
            :|.:|.....|||:||:||:|:|.|:|:| |||.|...|.:
Human   463 QEAKREPVGNDVATILSRRIAVEYSDSDD-DSEFDENDWSD 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAR	NP_001260368.1	None
WASF3	NP_006637.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..210		11/51 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..443		77/391 (20%)
		WH2_WAVE-3	437..502	CDD:409216	31/65 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159893
Domainoid	1	1.000	248	1.000	Domainoid score	I2143
eggNOG	1	0.900	-	-		E1_KOG1830
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2641
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54445
OrthoDB	1	1.010	-	-		D1183697at2759
OrthoFinder	1	1.000	-	-		FOG0000853
OrthoInspector	1	1.000	-	-		otm42006
orthoMCL	1	0.900	-	-		OOG6_106458
Panther	1	1.100	-	-	LDO	PTHR12902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4420
SonicParanoid	1	1.000	-	-		X835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800