DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33129 and TMEM214

DIOPT Version :9

Sequence 1:	NP_001285820.1	Gene:	CG33129 / 34514	FlyBaseID:	FBgn0053129	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_005264438.1	Gene:	TMEM214 / 54867	HGNCID:	25983	Length:	753	Species:	Homo sapiens

Alignment Length:	758	Identity:	172/758 - (22%)
Similarity:	286/758 - (37%)	Gaps:	170/758 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QWEVVSKSRKQ------------KNLDKKVSAHNEQKRIAAQLPKLEELLPTQRYRNLFGSSNNN 56
            :||||.|.|:.            :|......|:...|.......:....|..:.:.|:....|
Human    10 RWEVVKKGRRPGVGAGAGGRGGGRNRRALGEANGVWKYDLTPAIQTTSTLYERGFENIMKRQN-- 72

  Fly    57 NSKSHSPAKSSSSASSSSKANKSPVKKHTAKNASTQKRTTSAAASKPKTLELALRNITRDDFAAQ 121
              |...|..:.......:|  |.|.|..|..| ..||:      .:.::||.||:.:...|...:
Human    73 --KEQVPPPAVEPKKPGNK--KQPKKVATPPN-QNQKQ------GRFRSLEEALKALDVADLQKE 126

  Fly   122 LEQVKLSCPGSELRWLSHIALYFNEALSYD-CDPIFSGRSAQYPSNLASASLKYSIVEFLGSVGE 185
            |::.:....|:...||..:|.|.|..|... .:|..|..:..||.:|.|..|: .|:..|.:...
Human   127 LDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEPTLSQHTHDYPYSLVSRELR-GIIRGLLAKAA 190

  Fly   186 QNLEYFFYSLLDSMSTDLNN--NQTVAGYKLILQLIGQNWPNICSRNLAKTALLRNSYQNRSNIC 248
            .:||.||...|.:|..:|:.  .:::.||::.:|.|.|:.|.|.:.||.|...|..|:|:|...|
Human   191 GSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIATANLGKFLELLRSHQSRPAKC 255

  Fly   249 LSILWAIGQGGYQSLNEGVRVWQNLMLPNLELKQYTKFVVEYMERALSAAAVRKTADPLQINQQE 313
            |:|:||:||.|:.:|.||::||..:|||.|.:|..:.|.:.|::|.| ......|.....|..::
Human   256 LTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAITYLDRLL-LMHPNLTKGFGMIGPKD 319

  Fly   314 FFATYNALNAPYNHLPKEWQQSL-KRSARLLLQHYINSPVRHANIFLTLF-------------RE 364
            ||...:....|.|.|....|:.| :...||.:..:...|....:.:...|             :|
Human   320 FFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKPDSTLHTYFPSFLSRATPSCPPEMKKE 384

  Fly   365 ISAGSKQTNEIE---------------GCISCL-LSSGR-------------------------- 387
            :...|.....:|               ||.:.: |.:||
Human   385 LPVDSCLPRSLELHPQKMDPKRQHIQGGCAAWMALLTGRGSPLSTPRLCQPHAPSSLSLCRAVQL 449

  Fly   388 ----DDCL-------RVWRMNYKKQQLPSLLLLKAINDNWTTSTHELATSTVYHSFLQDVANL-- 439
                .:||       .|||..|.|....|.|||:.:..:|     |.....|..|..:.:.:|
Human   450 LSSLTECLTVDPLSASVWRQLYPKHLSQSSLLLEHLLSSW-----EQIPKKVQKSLQETIQSLKL 509

  Fly   440 -NEEL--QGSKRNEGHLDDLKEVLLSVQEKSSAQQKKNKQKAAAEKKKCGCCKWTLGSIFIIALI 501
             |:||  :||..|:    |:  |...:..|...||.:..:           ..||...:.::...
Human   510 TNQELLRKGSSNNQ----DV--VTCDMACKGLLQQVQGPR-----------LPWTRLLLLLLVFA 557

  Fly   502 AGALYYDTEVNGKGVFEKSATGKVLKNAGVLPHVQKSWYTVMGAGARGYKWAEVNVPPYAE---P 563
            .|.|.:|  :.....|:.|.||::|:::|.||..|::...:.....:||.|....:|.:..   .
Human   558 VGFLCHD--LRSHSSFQASLTGRLLRSSGFLPASQQACAKLYSYSLQGYSWLGETLPLWGSHLLT 620

  Fly   564 VIKTTCDL-WKLARNAACNAYQNGKGYFGAKWPVVAKFIDQYVPNSSGKIEAFAAGVSDLAASSY 627
            |::.:..| |         |:.|          ....|:       |....:..|...|...|..
Human   621 VVRPSLQLAW---------AHTN----------ATVSFL-------SAHCASHLAWFGDSLTSLS 659

  Fly   628 EKAAALIKEKVLVGRLSPENINQALNQTRNAALEYYNQFHKKV 670
            ::....:          |:::||.|...|...|    .||:.|
Human   660 QRLQIQL----------PDSVNQLLRYLRELPL----LFHQNV 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33129	NP_001285820.1	DUF2359	211..608	CDD:150784	108/472 (23%)
TMEM214	XP_005264438.1	DUF2359	217..749	CDD:150784	121/537 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147604
Domainoid	1	1.000	141	1.000	Domainoid score	I4748
eggNOG	1	0.900	-	-		E1_KOG4467
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9801
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4498
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48751
OrthoDB	1	1.010	-	-		D1409017at2759
OrthoFinder	1	1.000	-	-		FOG0007061
OrthoInspector	1	1.000	-	-		oto90214
orthoMCL	1	0.900	-	-		OOG6_109164
Panther	1	1.100	-	-	LDO	PTHR13448
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770