Protein Alignment Stam and STAM

DIOPT Version :9

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_003464.1
• Gene: STAM / 8027
• HGNCID: 11357
• Length: 540
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 236/593 - (39%)
• Similarity: 329/593 - (55%)
• Gaps: 74/593 - (12%)

  Fly     1 MGIFGQSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQ 65
            |.:|. ::|||.||||||||.||.::|.||||:||||..:....||||:::|||:.|.||||.||
Human     1 MPLFA-TNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQ 64

  Fly    66 AITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAENDYKNDRELDLI 130
            |:|||.|..:||||..||||.||||.:|...:|.|..|||..|::.::..|.: ::|||.:|.||
Human    65 ALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTD-EFKNDPQLSLI 128

  Fly   131 PALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKENKGSPKT 195
            .|:...|:::|..|..:|.:.::......|.:.|||..|::::||:|:||||||||||.:....|
Human   129 SAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTT 193

  Fly   196 GSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEIIH 260
            .|           :||||   |.|...:.:      .|.|||||:|||||||:|||||.|||||.
Human   194 LS-----------TLYPS---TSSLLTNHQ------HEGRKVRAIYDFEAAEDNELTFKAGEIIT 238

  Fly   261 VLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAAALQQKTE 325
            ||||||||||||...:|.||||||||||||:.:||.  |..:.|:...:...::::   ::.:.|
Human   239 VLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEM--IKTEKKTVQFSDDVQVET---IEPEPE 298

  Fly   326 AAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGPLIDAELERVDRKH 390
                     |..|||.|:|:||.:|...:|.|...|..|:|.||...||||||||.:||.:||||
Human   299 ---------PAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKH 354

  Fly   391 AQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPAAGGFPPA 455
            ::|::|:..:::|::||..||.:|...:.:.......:....:|..|:.:|..|  |.:|.:..|
Human   355 SELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGP--PPSGAYLVA 417

  Fly   456 QNYPGMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQNGHAAQMNSLPAHLTQPTGT 520
            .|....|...|. :|....|:.|||       :..|.....||.|...||..|::.:.:  ...|
Human   418 GNAQMSHLQSYS-LPPEQLSSLSQA-------VVPPSANPALPSQQTQAAYPNTMVSSV--QGNT 472

  Fly   521 APMPQPIYTQPTPVTTQQ-------QQQPLPQHPQQP---------PQQQG-QQPPQHPQNSYHI 568
            .|...|:|:.|...|...       .|...|..||.|         ||..| |||||
Human   473 YPSQAPVYSPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQ-------- 529

  Fly   569 DPQSQYAQ 576
             ||..|:|
Human   530 -PQQPYSQ 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	71/143 (50%)
		SH3_STAM	235..288	CDD:212754	43/52 (83%)
		GAT	340..412	CDD:281166	33/71 (46%)
STAM	NP_003464.1	VHS_STAM	9..142	CDD:239625	69/133 (52%)
		SH3_STAM1	213..267	CDD:212897	44/53 (83%)
		GAT	306..377	CDD:281166	33/70 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..540		16/46 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141240
Domainoid	1	1.000	148	1.000	Domainoid score	I4479
eggNOG	1	0.900	-	-		E1_KOG2199
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2091
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52024
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002740
OrthoInspector	1	1.000	-	-		otm41810
orthoMCL	1	0.900	-	-		OOG6_103033
Panther	1	1.100	-	-	O	PTHR45929
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	1	1.000	-	-		X1427
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790