DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Stam and Tom1l1

DIOPT Version :9

Sequence 1:NP_477448.1 Gene:Stam / 34505 FlyBaseID:FBgn0027363 Length:689 Species:Drosophila melanogaster
Sequence 2:NP_001344472.1 Gene:Tom1l1 / 71943 MGIID:1919193 Length:474 Species:Mus musculus


Alignment Length:621 Identity:130/621 - (20%)
Similarity:202/621 - (32%) Gaps:229/621 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FGQS--SPFDADV----EKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHV 62
            ||:|  .|:...|    ||||......::|...|.:||.:.|.....||.:||:.:|:.....|.
Mouse     3 FGKSHRDPYATSVGHLIEKATFAGVLTEDWGQFLHICDIINTTQDGPKDAVKALKKRISKNYNHK 67

  Fly    63 VMQ-AITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSL------KMRQVLKNWAEND 120
            .:| :::|:|....|||......:..::|..:  .|:....|:.:|      ::...:|.|::. 
Mouse    68 EIQLSLSLIDMCVQNCGPSFQSLIVKKEFIKD--TLVKLLNPRYTLPLETQNRILNFIKTWSQG- 129

  Fly   121 YKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELS 185
            :....::..:..:|..|.::|..|.. .|...:|..|.....|..|..|.:       |.|:...
Mouse   130 FPGGVDVSEVKEVYLDLLKKGVQFPP-SDGEPETRQEAGQISPNRPTSVPT-------APALSSI 186

  Fly   186 LKENKGSPKTGSVASTGTASAYPSLYPSFAGTGSS-----------APSAEASSAPAPEPRK--- 236
            :     :||..::          ||.|...|...|           ..:....:.|..|..:   
Mouse   187 I-----APKNPTI----------SLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIE 236

  Fly   237 -VRALY-----------DFEAAEENE-LTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTA 288
             :|.||           |.....||| :|.   |:|.|.:|.: |...||               
Mouse   237 LLRKLYKTGREMQERIMDLLVVVENEDVTM---ELIQVNEDLN-NAVLGY--------------- 282

  Fly   289 DLSVDPERLDINQQHKSAAAAGQRELDSAAALQQK---TEAAAAAAAAQPVEIDESKIDRLLHLL 350
                  ||...|||.               .|:||   |||...::                   
Mouse   283 ------ERFTRNQQR---------------LLEQKRNRTEATRTSS------------------- 307

  Fly   351 HEANPEDPSQDSDEMLQLEQEVHQMGPLIDAELERVDRKHAQLTQLS-SDLVDAI--NLYHTL-- 410
                  :||..|.::|.|...|    |:.......::..:|||:.|| |.|...|  |||.:|  
Mouse   308 ------EPSAPSCDLLDLSPIV----PVPTPNEGALNSVNAQLSGLSVSSLSPVITNNLYPSLQP 362

  Fly   411 MRDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPAAGGFP--PAQNYPGMHSMPYGPVPNPP 473
            .||       ..|:....:|.|                   ||  .:||....|:          
Mouse   363 QRD-------LLASEDIEIPTL-------------------FPQRTSQNLASSHT---------- 391

  Fly   474 TSAPSQAPGAPGGYLGQPQGQVPLPYQNGHAAQMNSLPAHLTQPTGTAPMPQPIYTQPTPVTTQQ 538
                                     |.|.|:   ||:   |.||..       ::|........|
Mouse   392 -------------------------YDNFHS---NSV---LLQPVS-------LHTATAAAAANQ 418

  Fly   539 QQQPLPQHPQQPPQQQGQ-QPPQHPQNSYHI---DP 570
            :..|||.  ..|..:.|. |||    |.|.:   ||
Mouse   419 RLPPLPS--SHPVLKDGDLQPP----NYYEVMEFDP 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
StamNP_477448.1 VHS_STAM 10..154 CDD:239625 33/154 (21%)
SH3_STAM 235..288 CDD:212754 15/68 (22%)
GAT 340..412 CDD:281166 19/76 (25%)
Tom1l1NP_001344472.1 VHS_ENTH_ANTH 14..154 CDD:321980 31/142 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..180 7/34 (21%)
GAT_TM1L1 198..289 CDD:260095 22/115 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..317 9/65 (14%)
Interaction with GRB2 392..395 1/2 (50%)
SH3-binding 420..424 1/3 (33%)
Interaction with PIK3R1 441..444 1/2 (50%)
SH2-binding 457..460
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831182
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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