DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stam and SH3GL3

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001311111.1	Gene:	SH3GL3 / 6457	HGNCID:	10832	Length:	360	Species:	Homo sapiens

Alignment Length:	310	Identity:	67/310 - (21%)
Similarity:	113/310 - (36%)	Gaps:	63/310 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 KLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQE--EDDIAKAIELSLKENKGSPKTGSV 198
            ||..|..|.:...|.|:|.|||          ::|...|  :.:.|...:|.:. |..|...|.|
Human    28 KLDDEFLDMERKIDVTNKVVAE----------ILSKTTEYLQPNPAYRAKLGML-NTVSKIRGQV 81

  Fly   199 ASTGTASAYPSL----------YPSFAGTGSSAPSA-----EASSAPAPEPRKVRALYDFEAAEE 248
            .:||    ||..          |....|..|:..:|     |:....|    :|:...|....:
Human    82 KTTG----YPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMA----EVKDSLDINVKQ- 137

  Fly   249 NELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRE 313
               ||.  :.:.:|.|.|......:.::.||               .|||.:.:.|........|
Human   138 ---TFI--DPLQLLQDKDLKEIGHHLKKLEG---------------RRLDYDYKKKRVGKIPDEE 182

  Fly   314 LDSAAALQQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGPL 378
            :..|....::::..|..:....:|.|..::.:|...:..|  .|..:.|.|:||..|...||...
Human   183 VRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAA--LDYHRQSTEILQELQSKLQMRIS 245

  Fly   379 IDAELERVDRKHAQLTQLSSDL--VDAINLYHT--LMRDDRAAAGHFAAA 424
            ..:.:.|.:.|...:.:.||:|  |...::..|  |....::..||...|
Human   246 AASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGLRSKRKSTQGHLGRA 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	6/17 (35%)
		SH3_STAM	235..288	CDD:212754	9/52 (17%)
		GAT	340..412	CDD:281166	18/75 (24%)
SH3GL3	NP_001311111.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87		8/31 (26%)
		Interaction with ARC. /evidence=ECO:0000250	218..254		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..271		5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030