DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stam and sh3gl1

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_989126.1	Gene:	sh3gl1 / 619364	XenbaseID:	XB-GENE-951561	Length:	366	Species:	Xenopus tropicalis

Alignment Length:	307	Identity:	78/307 - (25%)
Similarity:	128/307 - (41%)	Gaps:	61/307 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GIFGQSS-PFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLA--KDCLKAVMRRMGHTDPHVV 63
            |:.|::. .|..|:   ..|:|..|   .:||..:.:   .|||  ||.|...:::
Frog    91 GVLGETMIKFGKDL---GDESNFGD---ALLDAGESM---KRLAEVKDSLDIEVKQ--------- 137

  Fly    64 MQAITLLDALSNNCGKPL-----HL-EVASRDFETEFRRLLAKAQPKV-SLKMRQVLKNWAENDY 121
                ..||.|.|.|.|.|     || ::..|..:.::::   |.|.|: ..::||.::.:.|:
Frog   138 ----NFLDPLQNLCDKDLKEIQHHLKKLEGRRLDYDYKK---KRQGKIPDEELRQAMEKFIES-- 193

  Fly   122 KNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVS-----SQQEEDDIAKA 181
            |...|..:|..|...:.|           .|:..|...|.|......|.     |::.:|.:.::
Frog   194 KEVAETSMINLLDTDVEQ-----------VSQLTALVEAQLDYHRQAVQILDELSEKLKDRVRES 247

  Fly   182 IELSLKENKGSPKTG-----SVASTGTASAYPSLYPSFAGTGSSAPSA--EASSAPAPEPRKVRA 239
            ...:.:|.|..|:..     |..|.|..|...|..|:.:...|..|:.  ..||||..:| ..:|
Frog   248 SSRTKREFKPKPRESYEYAESEQSNGGFSNPSSKAPASSSFRSEKPARTNNRSSAPLDQP-CCKA 311

  Fly   240 LYDFEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFV 286
            ||||:...:.||.|...:||.:.:..|.||::|......|.||.|:|
Frog   312 LYDFDPENDGELGFRESDIITLTNQIDENWYEGMINGQSGFFPVNYV 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	35/152 (23%)
		SH3_STAM	235..288	CDD:212754	19/52 (37%)
		GAT	340..412	CDD:281166
sh3gl1	NP_989126.1	BAR_Endophilin_A	25..246	CDD:153276	43/192 (22%)
sh3gl1	NP_989126.1	SH3_Endophilin_A	307..361	CDD:212737	20/53 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030