DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stam and tom1l2

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_009304960.1	Gene:	tom1l2 / 560327	ZFINID:	ZDB-GENE-061013-3	Length:	527	Species:	Danio rerio

Alignment Length:	572	Identity:	114/572 - (19%)
Similarity:	198/572 - (34%)	Gaps:	185/572 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRM-GHTDPHVVMQAITLL 70
            |:|....:|:||..:..:::|:|.:::||.:.......||.::||.:|: |:.:...||..:|:|
Zfish    10 STPVGHCIERATDGSLQSEDWTLNMEICDIINETEDGPKDAMRAVKKRLNGNKNYREVMLTLTVL 74

  Fly    71 DALSNNCGKPLHLEVASRDFETEFRRLLAK-AQPK------VSLKMRQVLKNWAENDYKNDRELD 128
            :....|||...|:.|.:|||   ...:|.| ..||      |..|:..:::.||: .:::..:|.
Zfish    75 ETCVKNCGYRFHMLVTTRDF---IDGVLVKIISPKNNPPAIVQDKVLALIQAWAD-AFRSSPDLT 135

  Fly   129 LIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKENKGSP 193
            .:..:|.:::::|.:|                  |:.                 ||.......:|
Zfish   136 GVVHVYEEMKRKGIEF------------------PRS-----------------ELETLSPIHTP 165

  Fly   194 KTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEI 258
            :....|.......|            |||     ..|.|:|....|            ..|...:
Zfish   166 QRQQTAPEMDQQKY------------SAP-----VQPKPQPHPASA------------PPFTAPV 201

  Fly   259 IHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAAALQQK 323
            .|    :.|.            .|:..:...::..||::          ...:.|||
Zfish   202 AH----TSPQ------------MPNLHIAGPINPSPEQI----------CKLRSELD-------- 232

  Fly   324 TEAAAAAAAAQPVEIDESKIDRLLHLLHEANP--EDPSQDSDEMLQLEQEVHQMGPLIDAELERV 386
                        :....:|:  :..:|.|..|  |||| |.:.:.:|.:....|...|...:.||
Zfish   233 ------------IVRGNTKV--MSEMLTEMVPGQEDPS-DHELLQELNRTCRAMQQRIVELISRV 282

  Fly   387 DRKHA--QLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGAALYG-----AP 444
            ..:..  :|..::.||   .|::....|.:|..:|.   .|.|...||......|...     .|
Zfish   283 SNEEVTEELLHVNDDL---NNIFLRYERYERFRSGR---TAQGVNNGLREVLNEATEDNLIDLGP 341

  Fly   445 GYPAAGGFPPAQNYPGMHSMPYGPVPNPPTSAP--SQAP--------------GAPGGYLG---- 489
            |.||...       |.:.:.|  |...||:.||  |.:|              .:..|.|.
Zfish   342 GSPAVVS-------PRISATP--PSSLPPSVAPVRSASPVTLSSRLAGLDVGSDSVSGTLSSLAT 397

  Fly   490 -QPQ-----------GQVP----LPYQNGHAAQMNSLPAHLTQPTGTAPMPQ 525
             |||           |.||    .|:::..|:...:....:.|...||.:.|
Zfish   398 CQPQDDFDMFAQTRTGTVPEWKSAPFEDTKASSGVAPTLDVRQQNATAALDQ 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	37/151 (25%)
		SH3_STAM	235..288	CDD:212754	5/52 (10%)
		GAT	340..412	CDD:281166	18/75 (24%)
tom1l2	XP_009304960.1	VHS_Tom1	12..152	CDD:239623	38/161 (24%)
tom1l2	XP_009304960.1	GAT_TM1L2	221..312	CDD:260096	25/126 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1213216at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850