DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and Stam

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001102591.1	Gene:	Stam / 498798	RGDID:	1564499	Length:	547	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	235/595 - (39%)
Similarity:	325/595 - (54%)	Gaps:	83/595 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGIFGQSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQ 65
            |.:|. ::|||.||||||||.||.::|.||||:||||..:....||||:::|||:.|.||||.||
  Rat     1 MPLFA-TNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQ 64

  Fly    66 AITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAENDYKNDRELDLI 130
            |:|||.|..:||||..||||.||||.:|...:|.|..|||..|::.::..|.: ::|||.:|.||
  Rat    65 ALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTD-EFKNDPQLSLI 128

  Fly   131 PALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKENKGSPKT 195
            .|:...|:::|..|..:|.:.::......|.:.|||..|::::||:|:||||||||||.:..
  Rat   129 SAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQ--- 190

  Fly   196 GSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEIIH 260
                    |:...:||||   |.|...:.:      .|.|||||:|||||||:|||||.|||:|.
  Rat   191 --------AAPLSTLYPS---TSSLLTNHQ------HEGRKVRAVYDFEAAEDNELTFKAGEVIT 238

  Fly   261 VLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAAALQQKTE 325
            ||||||||||||...:|.||||||||||||:.:||.  |..:.|:...:...::::   ::.:.|
  Rat   239 VLDDSDPNWWKGETHQGMGLFPSNFVTADLTAEPEM--IKTEKKTVQFSDDVQIET---IEPEPE 298

  Fly   326 AAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGPLIDAELERVDRKH 390
                   .:|..|||.|:|:||.:|...:|.|...|..|:|.||...||||||||.:||.:||||
  Rat   299 -------PEPAFIDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKH 356

  Fly   391 AQLTQLSSDLVDAINLYHTLMRDD--------RAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYP 447
            ::|::|:..:::|::||..||.:|        ..:..::..|:|...|.:  :||.|..||  |.
  Rat   357 SELSELNVKVMEALSLYTKLMNEDPVYSVYAKSQSQQYYVQASGVSAPQV--YPGPAQSGA--YL 417

  Fly   448 AAG----------GFPPAQNYPGMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQNG 502
            .||          ..||.|    :.|:..|.||      ||..|..|     ..|.|...|....
  Rat   418 VAGNAQMTHLQSYSLPPEQ----LASISQGAVP------PSATPALP-----NQQAQASYPNAMV 467

  Fly   503 HAAQMNSLP--AHLTQPTGTAPMPQPIYTQPTPVTTQQQQQPLPQHPQQP---------PQQQGQ 556
            .:.|.||.|  |.:..|...| ....:...|.|......|.|.|...|.|         |...|.
  Rat   468 SSVQGNSYPSQASIYSPAAAA-AAVAVTAVPVPADVTIYQNPGPNMSQVPNYTLTSSTLPHTGGS 531

  Fly   557 QPPQHPQNSY 566
            |.|..||.:|
  Rat   532 QQPPQPQQAY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	71/143 (50%)
		SH3_STAM	235..288	CDD:212754	42/52 (81%)
		GAT	340..412	CDD:281166	33/71 (46%)
Stam	NP_001102591.1	VHS_STAM	9..142	CDD:239625	69/132 (52%)
		SH3_STAM1	213..267	CDD:212897	30/53 (57%)
		GAT	308..379	CDD:281166	22/70 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334906
Domainoid	1	1.000	148	1.000	Domainoid score	I4337
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2043
OMA	1	1.010	-	-		QHG52024
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002740
OrthoInspector	1	1.000	-	-		otm45950
orthoMCL	1	0.900	-	-		OOG6_103033
Panther	1	1.100	-	-	O	PTHR45929
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1427
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900