DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and gga3a

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001082823.2	Gene:	gga3a / 492643	ZFINID:	ZDB-GENE-041111-218	Length:	699	Species:	Danio rerio

Alignment Length:	716	Identity:	140/716 - (19%)
Similarity:	240/716 - (33%)	Gaps:	190/716 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GQSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQAITL 69
            |:|  .::.:.|||:.:|..:.|..|:..||::.......:..::.:..::........:||:|:
Zfish     6 GES--LESWLNKATNPSNRQEEWEYIIGFCDQINKELEGPQISVRLLAHKIQSPQEWESLQALTV 68

  Fly    70 LDALSNNCGKPLHLEVASRDFETEFRRLLA------KAQPKVSLKMRQVLKNWA---ENDYKNDR 125
            |:|...|||...|.||....|..|..:|::      :...:|..|:.::|.|.:   .::.|
Zfish    69 LEACMKNCGGRFHNEVGKFRFLNELIKLVSPKYLGDRVSERVKTKVIELLYNCSVALPDEAK--- 130

  Fly   126 ELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEE-------------DD 177
                |...|..|:::|...|:......:|:...    ||..|.|...:|:             :|
Zfish   131 ----IAEAYHMLKKQGIVTKDPEVHVDRTLIPS----PKTKNPVFDNEEKSKRLAELLKSKKPED 187

  Fly   178 IAKA---IELSLKENKG-SPKTGSVAST-----GTASAYPSLYPSFAGTGSSAPSAEASSAPAPE 233
            :.:|   |:..:||::. ..|..:..||     .:......:...|....|:....|.
Zfish   188 LQEANRIIKNMVKEDEALQQKVSNRVSTLEKVNNSVKLLNEMLSHFKTDESTQEDKEL------- 245

  Fly   234 PRKVRALYD---------FEAAEENELTFFA-GEIIHVLDDSDPNWWKGYNQRGEG--------- 279
               ::.||:         |..|.|.|....| |:|:|..||.. .....|.:..||
Zfish   246 ---LKDLYNDCDNLRTAVFRLATETEDDDSALGDILHASDDLS-RVINSYKKIVEGQTIVIDVPA 306

  Fly   280 LFPSNFVT-----------ADL---SVDPERLDIN-QQHKSAAAAGQRELDSAAALQQKTEAAAA 329
            ..||..:.           |||   :..|.|..:. .||..:.||....|.|....|..:...::
Zfish   307 STPSGCINDRSSSEILIDLADLGSGTPSPLRHGLTPPQHSDSPAADLLTLTSLMGAQPSSSNTSS 371

  Fly   330 AAAAQPVEIDESKIDRLLHLLHE-------ANPEDPSQDSDEMLQLEQEVHQ------MGPLID- 380
            .:::.......|::...|.||.|       .:.:..|:.|.|....|.:.:|      ..|:.|
Zfish   372 GSSSFQTSPPSSQLPSSLSLLDEELGSFGLGSLDSNSRTSAEKTTKEAQSNQWISSQISNPVTDF 436

  Fly   381 -----------------------AELER-VDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHF 421
                                   .:.|. :.:....|..|..|...:::.|.:|      ::...
Zfish   437 LCSSTPLNPPNSAAPPTSKTTSITDFENSLQQSFKDLVLLDLDKTKSLSNYSSL------SSREL 495

  Fly   422 AAAAGGFMPGLAGFPGAALYGAPGYPAAGGFPPAQNYPGMHSMPYGPV-----PNPPTSAPSQAP 481
            ||......|.|.....:|  |....|:||.....|::     .|..||     |..|:|..|.
Zfish   496 AAGKENIHPALNTLSLSA--GITPLPSAGSSAKPQSF-----APDSPVFRSLSPTLPSSQSSS-- 551

  Fly   482 GAPGGYLGQPQGQVPLPY-------------QNGHAAQMNSLPAHLTQPTGTAP----MPQPIYT 529
               |..:......|||..             ::|....::....|   |||...    :...:.|
Zfish   552 ---GSDISLTSVFVPLEAIKPSKECPVTAYDKDGVRVLLHFATDH---PTGRPDVLVIVVSMLNT 610

  Fly   530 QPTPVTTQQQQQPLPQHPQ---QPPQQQGQQP--PQHPQNSYHIDPQSQYAQVPPAVTQIQQPQQ 589
            .|..|.....|..:|:..:   |||......|  |..|               |.::|||.....
Zfish   611 APLLVRNVMLQAAVPKSMRVKLQPPSGTEMAPFNPFMP---------------PSSITQIMLLAN 660

  Fly   590 P 590
            |
Zfish   661 P 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	32/152 (21%)
		SH3_STAM	235..288	CDD:212754	17/82 (21%)
		GAT	340..412	CDD:281166	18/109 (17%)
gga3a	NP_001082823.2	VHS_GGA	8..145	CDD:239624	32/145 (22%)
		GAT_SF	212..297	CDD:322464	18/95 (19%)
		Alpha_adaptinC2	577..691	CDD:197886	21/103 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840