DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stam and grb2b

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_998200.1	Gene:	grb2b / 406308	ZFINID:	ZDB-GENE-040426-1975	Length:	217	Species:	Danio rerio

Alignment Length:	237	Identity:	59/237 - (24%)
Similarity:	97/237 - (40%)	Gaps:	63/237 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VASRDFETEFRRLLAKAQPKVSLKMRQVLK--------NWAENDYK---NDRELDLIPALYAKLR 138
            :|..||:       |.|..::|.|..::||        ||    ||   |.:: ..||..|.:::
Zfish     4 IAKYDFK-------ATADDELSFKRGEILKVLNEECDQNW----YKAELNGKD-GFIPKNYIEMK 56

  Fly   139 QEGYDFKNLGDKTSKTVAEK----AAALPKDPNVVSSQQEEDDIAKAIELS--------LKENKG 191
            ...:.|..:....::.:..|    .|.|.::     |:....|.:.:::..        |::..|
Zfish    57 AHPWFFGRIPRARAEEILNKQRHDGAFLIRE-----SESAPGDFSLSVKFGNDVQHFKVLRDGAG 116

  Fly   192 S-----PKTGSVAS------TGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEA 245
            .     .|..|:..      |.:.|....::           ..:....| ..|..|:||:||:.
Zfish   117 KYFLWVVKFNSLNELVDYHRTTSVSRNQQIF-----------LRDIEQVP-QHPTYVQALFDFDP 169

  Fly   246 AEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVT 287
            .|:.||.|..|:.|.|||:||||||||......|:||.|:||
Zfish   170 QEDGELGFRRGDFIQVLDNSDPNWWKGACHGQTGMFPRNYVT 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	18/79 (23%)
		SH3_STAM	235..288	CDD:212754	28/53 (53%)
		GAT	340..412	CDD:281166
grb2b	NP_998200.1	SH3_GRB2_N	1..56	CDD:212879	17/63 (27%)
		SH2_Grb2_like	56..150	CDD:199828	12/109 (11%)
		SH3_GRB2_C	160..212	CDD:212882	28/52 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030