DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stam and sh3gl1b

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_021333879.1	Gene:	sh3gl1b / 378838	ZFINID:	ZDB-GENE-031001-6	Length:	367	Species:	Danio rerio

Alignment Length:	324	Identity:	73/324 - (22%)
Similarity:	126/324 - (38%)	Gaps:	99/324 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGIFGQSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLA--KDCLKAVMRRMGHTDPHVV 63
            ||.:|:         :...|||..   ..:::|.:.:   .|||  ||.|...:::
Zfish    97 MGKYGR---------ELGEETNFG---GALMEVGESM---KRLAEVKDSLDIDVKQ--------- 137

  Fly    64 MQAITLLDALSNNCGKPL-----HL-EVASRDFETEFRRLLAKAQPKV-SLKMRQVLKNWAENDY 121
                ..:|.|...|.|.|     || ::..|..:.::::   |.|.|: ..::||.|:.:.|:
Zfish   138 ----NFIDPLQGLCDKDLREIQHHLKKLEGRRLDYDYKK---KRQGKIPDEELRQALEKFHES-- 193

  Fly   122 KNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQ--------QEEDDI 178
            |...|:.:...|                   :|..|:.:.|   .::|.||        |..|::
Zfish   194 KEVAEISMYNLL-------------------ETDIEQVSQL---SSLVESQLQYHRQAVQILDEL 236

  Fly   179 AKAIELSLKENKGSPK---------------TGSVASTG-TASAYPSL-----YPSFAGTGSSAP 222
            :..:...:|:.:..|:               |...::.| |.|:.|.:     |..|....:..|
Zfish   237 SDKLRDRMKDAQTRPRKEYIPKPKPVIDFGETNEQSNGGYTPSSAPPMRNAESYHQFGRITTRKP 301

  Fly   223 SAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFV 286
            ...|..|..      :||||||...|.||.|..|:||.:.:..|.||::|..:...|.||.|:|
Zfish   302 RLPAEQACC------KALYDFEPENEGELGFHEGDIITLTNQIDENWYEGMLRGQSGFFPLNYV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	28/152 (18%)
		SH3_STAM	235..288	CDD:212754	22/52 (42%)
		GAT	340..412	CDD:281166
sh3gl1b	XP_021333879.1	BAR_Endophilin_A	25..247	CDD:153276	40/204 (20%)
sh3gl1b	XP_021333879.1	SH3_Endophilin_A	309..362	CDD:212737	22/57 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030