DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and Gga3

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_006247781.1	Gene:	Gga3 / 360658	RGDID:	1309553	Length:	727	Species:	Rattus norvegicus

Alignment Length:	768	Identity:	152/768 - (19%)
Similarity:	244/768 - (31%)	Gaps:	272/768 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GQSSPFDADVEKATSETNTNDNWSLILDVCDKVT---TNPRLAKDCLKAVMRRMGHTDPHVVMQA 66
            |:|  .::.:.|||:.:|..::|..|:..||::.   ..|::|   ::.:..::........:||
  Rat     6 GES--LESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIA---VRLLAHKIQSPQEWEAVQA 65

  Fly    67 ITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAENDYKNDRELDLIP 131
            :|:|:|...|||:.||.||....|..|   |:....||.
  Rat    66 LTVLEACMKNCGRRLHNEVGKFRFLNE---LIKVVSPKY-------------------------- 101

  Fly   132 ALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKENKGSPKTG 196
                           |||:.|:.|.                      ||.|||........|:..
  Rat   102 ---------------LGDRVSEKVK----------------------AKVIELLFSWTLALPEEA 129

  Fly   197 SVASTGTASAYPSLYPSFAGTGSSAP--SAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEII 259
            .:     ..||..|  ...|...|.|  ..:.:..|:|.||....::|.|  |:::|      :.
  Rat   130 KI-----KDAYHML--KRQGIVQSDPPIPMDRTLIPSPPPRPKNPVFDDE--EKSKL------LA 179

  Fly   260 HVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAAALQQKT 324
            .:|...:|:                    ||.      :.||..||.
  Rat   180 KLLRSKNPD--------------------DLQ------EANQLIKSM------------------ 200

  Fly   325 EAAAAAAAAQPVEIDESKIDRL---LHLLHEAN-------------PEDPSQDSDEMLQLEQEVH 373
                       |:.||::|.::   ||.|.|.|             .::.|.::|:.|..|
  Rat   201 -----------VKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEFSSEADKELMKE---- 250

  Fly   374 QMGPLID-------------AELERVDRKHAQLTQLSSDLVDAINLYHTLMR------------- 412
                |.|             :|.|..|.....:.|.|.:|...||.|.|::.
  Rat   251 ----LFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQIINGEVTTSTV 311

  Fly   413 ---DDRAAAGHFAA--------AAGGFMPGLAGFPGAALYGAPGYP----AAGGFPPAQNYPGMH 462
               :..:..|:..|        ......|.||..|.....|.|..|    .:|  ||........
  Rat   312 PDSEGNSHCGNQGALIDLAELDTPSSSSPVLAPAPAPPTSGIPILPPPPQTSG--PPRSRSSSQA 374

  Fly   463 SMPYGP------------------VPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQNGHAAQMNS 509
            ..|.||                  :.:|..:||.::.|....:|.|.:....|.:.:.......|
  Rat   375 EAPSGPDSTNNALSLLDEELLCLGLSDPAPTAPKESAGNSPWHLFQNEPSSDLDFFSPRLVSAAS 439

  Fly   510 LPAH---LTQPTGT-----APMPQ--PIYTQPTPVTTQQ------QQQPLPQ-HPQQPPQQQGQQ 557
            .|:.   |..|..|     ||:|.  |....|....|..      ...|.|. .|:..|     :
  Rat   440 CPSEGSLLPPPVSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAEP-----E 499

  Fly   558 PPQHPQN--SYHIDPQSQYAQVPPAVTQIQQPQQ--PPAPHAY-MSPQHQQAPPPQGYQPGPNLY 617
            .|::|.:  |:.:|...|..:.....:.:.:|..  .|.|.|. :.|....|.|...:..||
  Rat   500 GPEYPSSSISHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPARPLLPFSTGP--- 561

  Fly   618 GPNGSPAVVNP--QSYMSPQQQQQQHPPPHDQFSQLHQQMAAMSMAGGPPVGA 668
               |||...:|  ||..|||:      .|....:.:|..:.::..:...||.|
  Rat   562 ---GSPLFQSPAFQSQGSPQK------GPELSLASVHVPLESIKPSSALPVTA 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	31/146 (21%)
		SH3_STAM	235..288	CDD:212754	7/52 (13%)
		GAT	340..412	CDD:281166	23/100 (23%)
Gga3	XP_006247781.1	VHS_GGA	8..146	CDD:239624	43/215 (20%)
		GAT_GGA3	213..299	CDD:260098	21/93 (23%)
		Alpha_adaptinC2	605..719	CDD:197886	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840