DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and Gga2

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001093989.1	Gene:	Gga2 / 293455	RGDID:	1304800	Length:	604	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	136/742 - (18%)
Similarity:	227/742 - (30%)	Gaps:	245/742 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GIFGQSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQA 66
            |..|.::..:..:.|||:.:....:||.|...|::|.|:|.........:..::........:.|
  Rat    21 GAPGSAAALELWLNKATNPSMAEQDWSAIQKFCEQVNTDPSGPTHAPWLLAHKIQSPQEREALYA 85

  Fly    67 ITLLDALSNNCGKPLHLEVASRDFETEFRRLL------AKAQPKVSLKMRQVLKNWA---ENDYK 122
            :|:|:...|:||:..|.|||...|..|..::|      |.|..||..::.::|.:|.   ..|.|
  Rat    86 LTVLEICMNHCGEKFHNEVAKFRFLNELIKVLSPKYLGAWATEKVKGRVIEILFSWTVWFPEDIK 150

  Fly   123 NDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLK 187
                   |...|..|:::|                   .:.:||.:
  Rat   151 -------IRDAYQMLKKQG-------------------IIKQDPKL------------------- 170

  Fly   188 ENKGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELT 252
                                              |..:....|:|.|:.:     |:|.||....
  Rat   171 ----------------------------------PMDKILPPPSPWPKSI-----FDADEEKSKL 196

  Fly   253 FFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSA 317
                 :..:|..:.|          |.|..:|.:..:|        :.::
  Rat   197 -----LTRLLKSNHP----------EDLQAANRLIKNL--------VKEE--------------- 223

  Fly   318 AALQQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGP---LI 379
               |:|:|..:...:|  ||...|.: |:|.               |||.:.:......|   .:
  Rat   224 ---QEKSEKVSRRVSA--VEEVRSHV-RVLR---------------EMLSMYRRPGHALPDQQAL 267

  Fly   380 DAELERVDRKHAQLTQLSSDLVD-----------------AINLYHTLMRDDRAAAGHFAAAAGG 427
            ....||.::....|.:|:||..|                 .:.||..:: :.|..||:...||.|
  Rat   268 QVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVV-EGRVNAGNAVPAAVG 331

  Fly   428 FMPGLAGFPGAALYGAPGYPAAGGFP------PAQNYPGMHSMPYGPVPN------PPTSAPSQA 480
            .:|....||...       |.....|      |:..:..:.::....||.      |......:.
  Rat   332 AIPASRVFPSPE-------PCGKNCPLIDLEAPSLLHQDLAALGINDVPTRNQVVIPSCCKDKKQ 389

  Fly   481 PGA----PGGY-----------LGQPQGQVPLPYQNGHAAQMNSLPAHLTQPTGTAPMP------ 524
            |||    .||.           |..||   |.|....:..| .|:|..:  |.||...|
  Rat   390 PGAITLMGGGIQSLSADRNLLDLFSPQ---PSPGPLNYVPQ-KSIPKEV--PPGTKASPGWSWEA 448

  Fly   525 QPIYTQPTPVTTQQQQQPLPQHPQQPPQQQGQQPP--QHPQNSYHIDPQSQYAQVP--PAVTQIQ 585
            .|:.:.|....|......:|....:|    ...||  .:.:|.:.|.........|  |.|..:.
  Rat   449 GPLASSPASQNTPLAHVFVPLESVKP----SSLPPIIVYDRNGFRILLHFSQTGAPGHPDVQVLL 509

  Fly   586 QPQQPPAPHAYMSPQHQQAPPPQ---GYQPGPN----LYGPNGSPAVVNPQSYMSPQQQQQQHPP 643
            ......|.........|.|.|..   ..||..:    .:.|...|||::....:.         .
  Rat   510 LTMMSTATQPVWDVMFQVAVPKSMRVKLQPASSSKLPAFSPLTPPAVISQMLLLD---------N 565

  Fly   644 PHDQFSQLHQQMAAMSMAGGPPVGAPG 670
            ||.:..:|..::....  ||.|....|
  Rat   566 PHKEPIRLRYKLTFNQ--GGQPFSEVG 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	35/152 (23%)
		SH3_STAM	235..288	CDD:212754	9/52 (17%)
		GAT	340..412	CDD:281166	16/91 (18%)
Gga2	NP_001093989.1	VHS_GGA	29..166	CDD:239624	35/162 (22%)
		ATP-synt_B	<186..>242	CDD:304375	16/103 (16%)
		GAT_SF	229..317	CDD:296121	19/106 (18%)
		Alpha_adaptinC2	482..596	CDD:197886	22/120 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334914
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840