DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and GRB2

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_002077.1	Gene:	GRB2 / 2885	HGNCID:	4566	Length:	217	Species:	Homo sapiens

Alignment Length:	240	Identity:	63/240 - (26%)
Similarity:	96/240 - (40%)	Gaps:	69/240 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VASRDFETEFRRLLAKAQPKVSLKMRQVLK--------NWAENDYK---NDRELDLIPALYAKLR 138
            :|..||:       |.|..::|.|...:||        ||    ||   |.:: ..||..|.:::
Human     4 IAKYDFK-------ATADDELSFKRGDILKVLNEECDQNW----YKAELNGKD-GFIPKNYIEMK 56

  Fly   139 QEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKENKGSP-------KTG 196
            ...:.|    .|..:..||:          :.|:|..|.     ...::|::.:|       |.|
Human    57 PHPWFF----GKIPRAKAEE----------MLSKQRHDG-----AFLIRESESAPGDFSLSVKFG 102

  Fly   197 S------VASTGTASAYPSLYPSFAGTGSSAPSAEASSAP-------------APEPRKVRALYD 242
            :      |...| |..|......|...........::|..             ..:|..|:||:|
Human   103 NDVQHFKVLRDG-AGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFD 166

  Fly   243 FEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVT 287
            |:..|:.||.|..|:.|||:|:||||||||......|:||.|:||
Human   167 FDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVT 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	19/79 (24%)
		SH3_STAM	235..288	CDD:212754	28/53 (53%)
		GAT	340..412	CDD:281166
GRB2	NP_002077.1	SH3_GRB2_N	1..56	CDD:212879	17/63 (27%)
		SH2_Grb2_like	56..150	CDD:199828	17/113 (15%)
		SH3_GRB2_C	160..212	CDD:212882	28/52 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030