Protein Alignment Stam and Tom1l1

DIOPT Version :9

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_001240788.1
• Gene: Tom1l1 / 287622
• RGDID: 1562626
• Length: 474
• Species: Rattus norvegicus
• Alignment Length: 591
• Identity: 125/591 - (21%)
• Similarity: 193/591 - (32%)
• Gaps: 198/591 - (33%)

  Fly     4 FGQS--SPFDAD----VEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHV 62
            ||:|  .|:...    :||||......::|...:.:||.:.|.....||.:||:.:|:.....|.
  Rat     3 FGKSHRDPYATSLGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHK 67

  Fly    63 VMQ-AITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSL------KMRQVLKNWAEND 120
            .:| :::|:|....|||......:..::|..:  .|:....|:.:|      ::...:|.|::.
  Rat    68 EIQLSLSLIDMCMQNCGPSFQSLIVKKEFVKD--TLVKLLNPRYTLPLETQNRILSFIKMWSQG- 129

  Fly   121 YKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELS 185
            :....::..:..:|..|.::|..|..| |...:|..|.....|..|..|.:       |.|:...
  Rat   130 FPGGVDVSEVKEVYLDLLKKGVQFPPL-DGEPETKQEAGQISPSRPTSVPT-------APALSSI 186

  Fly   186 LKENKGSPKTGSVASTGTASAYPSLYPSFAGTGSS-----------APSAEASSAPAPEPRK--- 236
            :     :||..::          ||.|...|...|           ..:....:.|..|..:
  Rat   187 I-----APKNPTI----------SLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIE 236

  Fly   237 -VRALY-----------DFEAAEENE-LTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTA 288
             :|.||           |.....||| :|.   |:|.|.:|.: |...||
  Rat   237 LLRKLYKTGREMQERIMDLLVVVENEDVTV---ELIQVNEDLN-NAILGY--------------- 282

  Fly   289 DLSVDPERLDINQQHKSAAAAGQRELDSAAALQQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEA 353
                  ||...|||.               .|:||         ..|.|.:.|
  Rat   283 ------ERFTRNQQR---------------LLEQK---------RNPTEANTS------------ 305

  Fly   354 NPEDPSQDSDEMLQL----EQEVHQMGPLIDAELERVDRKHAQLTQL---SSDLVDAINLYHTLM 411
              .:||..|.::|.|    ...|...|||        :..:|||:.|   |...|...|||.:|.
  Rat   306 --SEPSAPSCDLLNLGPVAPVPVSSEGPL--------NSVNAQLSGLNVSSQSPVITNNLYPSLQ 360

  Fly   412 RDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPAAGGFP--PAQNYPGMHSMPYGPVPNPPT 474
                                    |...|..:........||  .:||....|:  |...|:..:
  Rat   361 ------------------------PQMDLLASEDTEVPTLFPQRTSQNLASSHT--YDNFPDHSS 399

  Fly   475 SAPSQ------APGAPGGYLGQPQGQVPLPYQNGHAAQMNSLPAHLTQPTG---------TAPMP 524
            |...|      ||.||..     |...|||  :.|....||    ..||..         .||..
  Rat   400 SVLLQPVSLHTAPAAPSS-----QRLPPLP--SNHPVLKNS----ALQPPSYYEVMEFDPLAPTT 453

  Fly   525 QPIYTQ 530
            :.||.:
  Rat   454 EAIYEE 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	32/154 (21%)
		SH3_STAM	235..288	CDD:212754	15/68 (22%)
		GAT	340..412	CDD:281166	20/78 (26%)
Tom1l1	NP_001240788.1	VHS_Tom1	14..154	CDD:239623	29/142 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..175		5/20 (25%)
		GAT_TM1L1	198..289	CDD:260095	22/115 (19%)
		Interaction with GRB2. /evidence=ECO:0000250	391..394		1/2 (50%)
		SH3-binding. /evidence=ECO:0000250	420..424		1/3 (33%)
		Interaction with PIK3R1. /evidence=ECO:0000250	441..444		0/2 (0%)
		SH2-binding. /evidence=ECO:0000250	457..460		1/3 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840