Protein Alignment Stam and GGA1

DIOPT Version :9

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_001350700.1
• Gene: GGA1 / 26088
• HGNCID: 17842
• Length: 656
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 149/787 - (18%)
• Similarity: 238/787 - (30%)
• Gaps: 300/787 - (38%)

  Fly    11 DADVEKATSETNTNDNWSLILDVCDKVTTN---PRLAKDCLKAVMRRMGHTDPHVVMQAIT---- 68
            :|.:.:||:..|...:|:.|...|:::..:   |.||   .:.:..::........:||:|
Human    11 EARINRATNPLNKELDWASINGFCEQLNEDFEGPPLA---TRLLAHKIQSPQEWEAIQALTVRRG 72

  Fly    69 -------------LLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAEND 120
                         :|:....:|||..|.||....|..|   |:....||.
Human    73 EATIRPPPCDDTKVLETCMKSCGKRFHDEVGKFRFLNE---LIKVVSPKY--------------- 119

  Fly   121 YKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEK--------AAALPKDPNVVSSQQEEDD 177
                                      ||.:||:.|..|        ...||          ||..
Human   120 --------------------------LGSRTSEKVKNKILELLYSWTVGLP----------EEVK 148

  Fly   178 IAKAIELSLKEN--KGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRAL 240
            ||:|.::..|:.  |..||                          .|.......|.|.|:.|
Human   149 IAEAYQMLKKQGIVKSDPK--------------------------LPDDTTFPLPPPRPKNV--- 184

  Fly   241 YDFEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADL-SVDPERLDINQQHK 304
             .||..|::::      :..:|..|.|          |.|..:|.:..:: ..|.:|::...:..
Human   185 -IFEDEEKSKM------LARLLKSSHP----------EDLRAANKLIKEMVQEDQKRMEKISKRV 232

  Fly   305 SAAAAGQRELDSAAAL-----QQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDE 364
            :|.    .|:::...|     ...::..|||.:::                            |.
Human   233 NAI----EEVNNNVKLLTEMVMSHSQGGAAAGSSE----------------------------DL 265

  Fly   365 MLQLEQEVHQMGPL---IDAELERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAG 426
            |.:|.|...:|.|.   :.::.|..|...|::.|.:.:|...||||..|:|.:.....    |..
Human   266 MKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGD----ATA 326

  Fly   427 GFMPG-------LAGF---PGAALYGA----PGYPAAGGFP------------------------ 453
            |.:||       |:|.   |....|.|    ||..|:...|
Human   327 GSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSG 391

  Fly   454 PAQNYPGMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQN--------GHAAQMNSL 510
            |:.:..|.:|........||..|.:|||...    .:|..|..||..:        |......||
Human   392 PSLDGTGWNSFQSSDATEPPAPALAQAPSME----SRPPAQTSLPASSGLDDLDLLGKTLLQQSL 452

  Fly   511 PAHLTQPTGTAPMPQPIYT------------QPTPVTTQQQQQPLPQHPQQPPQQ---------- 553
            |....|.......|.|..|            .|:...|.......|: |.:||||
Human   453 PPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPE-PPRPPQQPVPTELSLAS 516

  Fly   554 -----QGQQPPQ------HPQNSYHI------DPQSQYAQV-PPAVTQIQQPQQPPAPHAYMS-- 598
                 :..:|..      :.|:.:.|      ||....:.| ...|:.:....||.....:.|
Human   517 ITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAV 581

  Fly   599 PQHQQA--PPPQGYQ-PGPNLYGPNGSPAVV-------NPQS-----------YMSPQQQQQ--- 639
            |:..:.  .||.|.: |.   :.|...|:.:       |||.           .|..|...:
Human   582 PKVMKVKLQPPSGTELPA---FNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGD 643

  Fly   640 --QHPPP 644
              |.|||
Human   644 VDQFPPP 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	29/162 (18%)
		SH3_STAM	235..288	CDD:212754	10/52 (19%)
		GAT	340..412	CDD:281166	16/74 (22%)
GGA1	NP_001350700.1	VHS_GGA	9..164	CDD:239624	39/209 (19%)
		GAT_GGA1_GGA2	227..316	CDD:260097	22/120 (18%)
		Alpha_adaptinC2	534..648	CDD:197886	22/116 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840