Protein Alignment Stam and Gga3

DIOPT Version :9

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_766636.2
• Gene: Gga3 / 260302
• MGIID: 2384159
• Length: 718
• Species: Mus musculus
• Alignment Length: 772
• Identity: 156/772 - (20%)
• Similarity: 245/772 - (31%)
• Gaps: 289/772 - (37%)

  Fly     5 GQSSPFDADVEKATSETNTNDNWSLILDVCDKVT---TNPRLAKDCLKAVMRRMGHTDPHVVMQA 66
            |:|  .::.:.|||:.:|..::|..|:..||::.   ..|::|   ::.:..::........:||
Mouse     6 GES--LESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIA---VRLLAHKIQSPQEWEAVQA 65

  Fly    67 ITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAENDYKNDRELDLIP 131
            :|:|:|...|||:.||.||....|..|   |:....||.
Mouse    66 LTVLEACMKNCGRRLHNEVGKFRFLNE---LIKVVSPKY-------------------------- 101

  Fly   132 ALYAKLRQEGYDFKNLGDKTSKTVAEK--------AAALPKDPNVVSSQQEEDDIAKAIELSLKE 188
                           |||:.|:.|..|        ..|||          ||..|..|..:..::
Mouse   102 ---------------LGDRVSEKVKTKVIELLFSWTLALP----------EEAKIKDAYHMLKRQ 141

  Fly   189 NKGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTF 253
                         |...:.|.:            ..:.:..|:|.||....::|.|  |:::|
Mouse   142 -------------GIVQSDPPI------------PMDRTLIPSPPPRPKNPVFDDE--EKSKL-- 177

  Fly   254 FAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAA 318
                :..:|...:|:                    ||.      :.|:..||.
Mouse   178 ----LARLLKSKNPD--------------------DLQ------EANRLIKSM------------ 200

  Fly   319 ALQQKTEAAAAAAAAQPVEIDESKIDRL---LHLLHEAN-------------PEDPSQDSDEMLQ 367
                             |:.||::|.::   ||.|.|.|             .::.|.|:|:.|.
Mouse   201 -----------------VKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEYSSDADKELM 248

  Fly   368 LEQEVHQMGPLID-------------AELERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAG 419
            .|        |.|             :|.|..|.....:.|.|.:|...||.|.|:: :.:...|
Mouse   249 KE--------LFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTII-EGQIVNG 304

  Fly   420 HFAAAAGGFMP-----GLAGFPGA----ALYGAPGYPAAGGFPPAQNYPGMHSMPYGPVPNPPTS 475
            ....:.   ||     ...|..||    |...||...:....||....|   .:|    |.|.||
Mouse   305 EVTTST---MPDSEGNSHCGNQGALIDLAELDAPSNSSPALAPPTSGIP---ILP----PPPQTS 359

  Fly   476 AP------SQAPGAPGG---------------YLGQPQGQVPLPYQNGHAAQ----MNSLPAHL- 514
            .|      |||...||.               .||........|.::..::|    .|..|:.|
Mouse   360 GPPRSRSSSQAEAPPGSDSTNNALSLLDEELLCLGLTDPAPTAPKESPGSSQWHLFQNEPPSDLD 424

  Fly   515 ---TQPTGTAPMPQPIYTQPTPVTTQQQQQ-------PLPQHPQQPPQ--------QQGQQP--- 558
               .:|...|..|......|.||:|....|       |.|..|...|.        ..|..|
Mouse   425 FFSPRPVPAASCPSDGPQLPPPVSTSSMSQAPLPAAFPAPVVPASAPTHSTGSFMFSSGPAPALA 489

  Fly   559 -------PQHPQN--SYHIDPQSQYAQVPPAVTQIQQPQQ--PPAPHAY-MSPQHQQAPPPQGYQ 611
                   |::|.:  |:.:|...|..:.....:.:.:|..  .|.|.|. :.|....|.|...:.
Mouse   490 PKAEPKGPEYPSSSTSHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASAPARPLLPFS 554

  Fly   612 PGPNLYGPNGSPAVVNPQSYMSPQQQQQQHPPPHDQFSQLHQQMAAMSMAGGPPVGA 668
            .||      |||..   ||..|||:      .|....:.:|..:.::..:...||.|
Mouse   555 TGP------GSPLF---QSQGSPQK------GPELSLASVHVPLESIKPSSALPVTA 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	31/146 (21%)
		SH3_STAM	235..288	CDD:212754	7/52 (13%)
		GAT	340..412	CDD:281166	24/100 (24%)
Gga3	NP_766636.2	VHS_GGA	8..146	CDD:239624	42/209 (20%)
		GAT_GGA3	213..299	CDD:260098	22/94 (23%)
		Unstructured hinge	299..588		68/313 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..381		16/53 (30%)
		Autoinhibitory. /evidence=ECO:0000250	387..391		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..455		12/59 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..506		4/28 (14%)
		Alpha_adaptinC2	596..710	CDD:197886	1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840