Protein Alignment Stam and GGA2

DIOPT Version :10

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_055859.1
• Gene: GGA2 / 23062
• HGNCID: 16064
• Length: 613
• Species: Homo sapiens
• Alignment Length: 744
• Identity: 126/744 - (16%)
• Similarity: 227/744 - (30%)
• Gaps: 243/744 - (32%)

  Fly     5 GQSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQAITL 69
            |.::..:..:.|||..:.:..:||.|.:.|::|.|:|.........:..::........:.|:|:
Human    21 GPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTV 85

  Fly    70 LDALSNNCGKPLHLEVASRDFETEFRRLLAK------AQPKVSLKMRQVLKNWA---ENDYKNDR 125
            |:...|:||:..|.|||...|..|..::|:.      |..||..::.::|.:|.   ..|.|
Human    86 LEMCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIK--- 147

  Fly   126 ELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKENK 190
                |...|..|:::|                   .:.:||.:
Human   148 ----IRDAYQMLKKQG-------------------IIKQDPKL---------------------- 167

  Fly   191 GSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFA 255
                                           |..:....|:|.|:.  :::|.:..:...||
Human   168 -------------------------------PVDKILPPPSPWPKS--SIFDADEEKSKLLT--- 196

  Fly   256 GEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAAAL 320
                .:|..:.|          |.|..:|.:..:|        :.::
Human   197 ----RLLKSNHP----------EDLQAANRLIKNL--------VKEE------------------ 221

  Fly   321 QQKTE-AAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGPLIDAELE 384
            |:|:| .:...:|.:.|......:..:|.:........|.|::                :....|
Human   222 QEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEA----------------LQVVYE 270

  Fly   385 RVDRKHAQLTQLSSDLVD-----------------AINLYHTLMRDDRAAAGHFAAAAGGFMPGL 432
            |.::....|.:|:||..|                 .:.||..:| :.|...|:...::.|.:|..
Human   271 RCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVM-EGRVTFGNRVTSSLGDIPVS 334

  Fly   433 AGF--PGAALYGAP--------GYPAAGGFPPAQNYPGMHSMPYGPVP---------------NP 472
            ..|  |...:...|        |....|...|:..:..:.::.....|               ||
Human   335 RVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDAPVTGMVSGQNCCEEKRNP 399

  Fly   473 PTSAPSQAPGAPGGYLGQPQGQ---------VPLPYQNGHAAQMNSLPAHLTQPTGTAPMP---- 524
            .:|.      .|||.:..|...         .|.|....:.:| .|:|..:  |.||...|
Human   400 SSST------LPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQ-KSVPKEV--PPGTKSSPGWSW 455

  Fly   525 --QPIYTQPTPVTTQQQQQPLPQHPQQPPQQQGQQPP--QHPQNSYHIDPQSQYAQVP--PAVTQ 583
              .|:...|:...|...|..:|....:|    ...||  .:.:|.:.|.........|  |.|..
Human   456 EAGPLAPSPSSQNTPLAQVFVPLESVKP----SSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQV 516

  Fly   584 IQQPQQPPAPHAYMSPQHQQAPPPQ---GYQPGPN----LYGPNGSPAVVNPQSYMSPQQQQQQH 641
            :.......||........|.|.|..   ..||..:    .:.|...|||::....:.
Human   517 LLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLD-------- 573

  Fly   642 PPPHDQFSQLHQQMAAMSMAGGPPVGAPG 670
             .||.:..:|..::....  ||.|....|
Human   574 -NPHKEPIRLRYKLTFNQ--GGQPFSEVG 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..141	CDD:340770	33/139 (24%)
		SH3_STAM	235..288	CDD:212754	8/52 (15%)
		GAT_STAM	337..413	CDD:410593	13/92 (14%)
		PHA03247	<436..526	CDD:223021	22/127 (17%)
GGA2	NP_055859.1	VHS_GGA2	25..163	CDD:340807	34/163 (21%)
		GGA_N-GAT	185..224	CDD:465702	10/81 (12%)
		GAT_GGA1_GGA2	227..314	CDD:410586	14/102 (14%)
		Unstructured hinge	316..483		32/175 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..414		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	435..466		9/33 (27%)
		Alpha_adaptinC2	491..605	CDD:197886	23/120 (19%)