DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and Gga1

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_666041.1	Gene:	Gga1 / 106039	MGIID:	2146207	Length:	635	Species:	Mus musculus

Alignment Length:	686	Identity:	140/686 - (20%)
Similarity:	219/686 - (31%)	Gaps:	234/686 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DADVEKATSETNTNDNWSLILDVCDKVTTN---PRLAKDCLKAVMRRMGHTDPHVVMQAITLLDA 72
            :|.:.:||:..|...||:.|...|:::..:   |.||   .:.:..::........:||:|:|:.
Mouse    11 EARINRATNPLNKELNWASINSFCEQLNEDFEGPPLA---TRLLAHKIQSPQEWEAIQALTVLET 72

  Fly    73 LSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAENDYKNDRELDLIPALYAKL 137
            ...:|||..|.||....|..|   |:....||.
Mouse    73 CMKSCGKRFHDEVGKFRFLNE---LIKVVSPKY-------------------------------- 102

  Fly   138 RQEGYDFKNLGDKTSKTVAEK--------AAALPKDPNVVSSQQEEDDIAKAIELSLKEN--KGS 192
                     ||.:||:.|..|        ...||          ||..||:|.::..|:.  |..
Mouse   103 ---------LGSRTSEKVKSKILELLYSWTVCLP----------EEVKIAEAYQMLKKQGIVKSD 148

  Fly   193 PKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFAGE 257
            ||....|          ::|                .|.|.|:.|    .||..|::::
Mouse   149 PKLPEDA----------IFP----------------LPPPRPKNV----IFEDEEKSKM------ 177

  Fly   258 IIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADL-SVDPERLDINQQHKSAAAAGQRELDSAAALQ 321
            :..:|..|.|          |.|..:|.:..:: ..|.:|::...:..:|.    .|:::...|.
Mouse   178 LARLLKSSHP----------EDLRAANKLIKEMVQEDQKRMEKISKRVNAI----EEVNNNVKLL 228

  Fly   322 QKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGPL---IDAEL 383
            .:...:.:..||.                        |...|.|.:|.|...:|.|.   :.::.
Mouse   229 TEMVMSHSQGAAS------------------------SSSEDLMKELYQRCERMRPTLFRLASDT 269

  Fly   384 ERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPA 448
            |..|...|::.|.:.:|...||||..|:|.:.......|::..|....|....|..|      |.
Mouse   270 EDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATASSIPGSTSALLDLSGLDL------PP 328

  Fly   449 AGGFPPA-QNYPGMHSMPYG-----------------PVPNPPTSAPSQAPG-----APGGYLGQ 490
            .|...|| ...||..|.|..                 ..|.||:...|.:.|     :..|
Mouse   329 PGTTQPATPTRPGNQSSPEQLSASVSLLDDELMSLGLSDPTPPSGTSSDSVGWDNFQSSDG---- 389

  Fly   491 PQGQVPLPYQNGHAAQMNSLPAHLTQPTGTAPMPQPIYTQPTPVTTQQ-QQQPLPQHPQQPPQQQ 554
            .:..||.|.|         .|:...:|...||.|.........:..:. .||.||...|| .:.:
Mouse   390 TESSVPPPAQ---------APSMDCRPPAQAPPPTSSGLDDLDLLGKTLMQQALPPEAQQ-VRWE 444

  Fly   555 GQQPPQHPQNSYHIDPQSQYAQVPPAVT--QIQQPQQPPAPHAYMSPQHQQAPPPQGYQPGPNLY 617
            .|||                   .|.:|  .:|.....|:|.| .|..|..:|.|    |||
Mouse   445 KQQP-------------------APRLTLRDLQSKSSSPSPGA-ASLLHTTSPEP----PGP--- 482

  Fly   618 GPNGSPA------------VVNPQSYMSPQQQQQQH 641
            .|..:|.            .:.|.|.: |.....||
Mouse   483 PPQATPTEFSLTSITVPLESIKPSSIL-PVTVYDQH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	30/145 (21%)
		SH3_STAM	235..288	CDD:212754	10/52 (19%)
		GAT	340..412	CDD:281166	17/74 (23%)
Gga1	NP_666041.1	VHS_GGA	9..147	CDD:239624	40/192 (21%)
		Interaction with ARF3. /evidence=ECO:0000250	114..273		42/242 (17%)
		DUF327	<180..234	CDD:294489	11/67 (16%)
		GAT_GGA1_GGA2	210..298	CDD:260097	22/115 (19%)
		Unstructured hinge	299..505		52/252 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..349		13/49 (27%)
		Autoinhibitory. /evidence=ECO:0000250	357..361		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..422		15/72 (21%)
		DUF1176	<382..>445	CDD:284160	16/76 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..490		13/42 (31%)
		Alpha_adaptinC2	513..627	CDD:197886	2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840