Protein Alignment Stam and TOM1

DIOPT Version :9

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_001129204.1
• Gene: TOM1 / 10043
• HGNCID: 11982
• Length: 493
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 127/596 - (21%)
• Similarity: 218/596 - (36%)
• Gaps: 161/596 - (27%)

  Fly     7 SSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRR-MGHTDPHVVMQAITLL 70
            |||....:||||..:..:::|:|.:::||.:.......||.|:||.:| :|:.:.|.||.|:|:|
Human    10 SSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVL 74

  Fly    71 DALSNNCGKPLHLEVASRDF--ETEFRRLLAKAQPK--VSLKMRQVLKNWAENDYKNDRELDLIP 131
            :....|||...|:.|||:||  ....|.:|.|..|.  |..|:..::::||: .:::..:|..:.
Human    75 ETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWAD-AFRSSPDLTGVV 138

  Fly   132 ALYAKLRQEGYDFKNLG-DKTS------KTVAEKAAALPKDPNVVSSQQEEDDIAKAIELSLKEN 189
            .:|..||::|.:|.... |..|      :||........:|.....|.|:||....|..|
Human   139 TIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAPL----- 198

  Fly   190 KGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAP-APEPRKVRALYDFEAAEENELTF 253
                                          .||...:...| ||.|.::..|       .:||..
Human   199 ------------------------------PAPPILSGDTPIAPTPEQIGKL-------RSELEM 226

  Fly   254 FAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSAA 318
            .:|.:            :..::....|.|:....|||.:..|   :|:              :..
Human   227 VSGNV------------RVMSEMLTELVPTQAEPADLELLQE---LNR--------------TCR 262

  Fly   319 ALQQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQLEQEVHQMGPLIDAEL 383
            |:||                      |:|.|:.:...|   |.::|:|.:...::.    :....
Human   263 AMQQ----------------------RVLELIPQIANE---QLTEELLIVNDNLNN----VFLRH 298

  Fly   384 ERVDR-KHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYP 447
            ||.:| :..|.|:..|:...|.:|..  |..|.||.|:.::...|...|    ..:...|.....
Human   299 ERFERFRTGQTTKAPSEAEPAADLID--MGPDPAATGNLSSQLAGMNLG----SSSVRAGLQSLE 357

  Fly   448 AAGGFPPAQNYPGMHSMPYG-PVPNPPTSAPSQAPGAPGGYLG------QPQGQVPLPYQNGHAA 505
            |:|..   ::...|.::..| .:.:.......:||.|..|..|      |..|.:|:.    .|.
Human   358 ASGRL---EDEFDMFALTRGSSLADQRKEVKYEAPQATDGLAGALDARQQSTGAIPVT----QAC 415

  Fly   506 QMNSLPAHLTQPTGTAPMPQPIYTQPTPVTTQQQ------------------QQPLPQHPQQPPQ 552
            .|..:...|:...|...      .:|..||::.:                  ..|..:.|..||
Human   416 LMEDIEQWLSTDVGNDA------EEPKGVTSEGKFDKFLEERAKAADRLPNLSSPSAEGPPGPP- 473

  Fly   553 QQGQQPPQHPQ 563
             .|..|.:..|
Human   474 -SGPAPRKKTQ 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	46/155 (30%)
		SH3_STAM	235..288	CDD:212754	6/52 (12%)
		GAT	340..412	CDD:281166	15/72 (21%)
TOM1	NP_001129204.1	VHS_Tom1	12..152	CDD:239623	44/140 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..212		10/75 (13%)
		GAT_TOM1	214..308	CDD:260094	25/158 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..336		10/30 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840