Protein Alignment Stam and TOM1L1

DIOPT Version :10

• Sequence 1: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: XP_054170610.1
• Gene: TOM1L1 / 10040
• HGNCID: 11983
• Length: 625
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 117/650 - (18%)
• Similarity: 194/650 - (29%)
• Gaps: 268/650 - (41%)

  Fly     4 FGQS--SPFDADV----EKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHV 62
            ||:|  .|:...|    ||||......::|...:.:||.:.|.....||.:||:.:|:.....|.
Human   152 FGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHK 216

  Fly    63 VMQ-AITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSL------KMRQVLKNWAEND 120
            .:| .::|:|....|||......:..::|..|  .|:....|:.:|      ::...:|.|::.
Human   217 EIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKE--NLVKLLNPRYNLPLDIQNRILNFIKTWSQG- 278

  Fly   121 YKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELS 185
            :....::..:..:|..|.::|..|.                 |.:....:::||...|:
Human   279 FPGGVDVSEVKEVYLDLVKKGVQFP-----------------PSEAEAETARQETAQIS------ 320

  Fly   186 LKENKGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEA-SSAPAPEPRKVRALYDFEAAEEN 249
                 .:|.|                        |.|:|.| ||..||:
Human   321 -----SNPPT------------------------SVPTAPALSSVIAPK---------------- 340

  Fly   250 ELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQREL 314
                                                 .:.:::.||:  |.:.|.
Human   341 -------------------------------------NSTVTLVPEQ--IGKLHS---------- 356

  Fly   315 DSAAALQQKTEAAAAAAAAQPVEIDESKID-RLLH-LLHEANPEDPSQDSDEMLQ------LEQE 371
                                  |:|..|:: |::. :|.|..|...:.:..|:||      .|.:
Human   357 ----------------------ELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQ 399

  Fly   372 VHQMGPLIDAELERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFP 436
            ...|..|:..|.|.|.   .:|.|::.||.:||..|....|:.:...
Human   400 ERIMDLLVVVENEDVT---VELIQVNEDLNNAILGYERFTRNQQRIL------------------ 443

  Fly   437 GAALYGAPGYPAAGGFPPAQNYPGMHSMPYGPVPNPPTSAPSQ-------APGAPGGYLGQ---- 490
                              .||.....:......|    |||||       :|..|...||:
Human   444 ------------------EQNKNQKEATNTTSEP----SAPSQDLLDLSPSPRMPRATLGELNTM 486

  Fly   491 -----------PQGQVPLPYQNGHAAQMNSLPAHLTQPTGTAPMPQ------------------- 525
                       |...|....:.....|||.|....|:   ..|..|
Human   487 NNQLSGLNFSLPSSDVTNNLKPSLHPQMNLLALENTE---IPPFAQRTSQNLTSSHAYDNFLEHS 548

  Fly   526 -PIYTQPTPVTT------QQQQQPLP-QHPQQPPQQQGQQPPQHPQNSYHIDPQSQYAQVPPAVT 582
             .::.||..:.|      .|...||| .||..  .:...|||    |.|.:   .::..:.||||
Human   549 NSVFLQPVSLQTIAAAPSNQSLPPLPSNHPAM--TKSDLQPP----NYYEV---MEFDPLAPAVT 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..141	CDD:340770	30/141 (21%)
		SH3_STAM	235..288	CDD:212754	0/52 (0%)
		GAT_STAM	337..413	CDD:410593	23/83 (28%)
		PHA03247	<436..526	CDD:223021	21/131 (16%)
TOM1L1	XP_054170610.1	PHA03247	<17..159	CDD:223021	3/6 (50%)
		VHS_Tom1L1	163..299	CDD:340794	30/138 (22%)
		GAT_TM1L1	348..439	CDD:410584	28/127 (22%)