DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and TOM1L1

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_005477.2	Gene:	TOM1L1 / 10040	HGNCID:	11983	Length:	476	Species:	Homo sapiens

Alignment Length:	648	Identity:	118/648 - (18%)
Similarity:	191/648 - (29%)	Gaps:	264/648 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FGQS--SPFDADV----EKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHV 62
            ||:|  .|:...|    ||||......::|...:.:||.:.|.....||.:||:.:|:.....|.
Human     3 FGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHK 67

  Fly    63 VMQ-AITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSL------KMRQVLKNWAEND 120
            .:| .::|:|....|||......:..::|..|  .|:....|:.:|      ::...:|.|::.
Human    68 EIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKE--NLVKLLNPRYNLPLDIQNRILNFIKTWSQG- 129

  Fly   121 YKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIELS 185
            :....::..:..:|..|.::|..|.                 |.:....:::||...|:
Human   130 FPGGVDVSEVKEVYLDLVKKGVQFP-----------------PSEAEAETARQETAQIS------ 171

  Fly   186 LKENKGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEA-SSAPAPEPRKVRALYDFEAAEEN 249
                 .:|.|                        |.|:|.| ||..||:
Human   172 -----SNPPT------------------------SVPTAPALSSVIAPK---------------- 191

  Fly   250 ELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQREL 314
                                                 .:.:::.||:  |.:.|.        ||
Human   192 -------------------------------------NSTVTLVPEQ--IGKLHS--------EL 209

  Fly   315 DSAAALQQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDEMLQ------LEQEVH 373
            |..     |......:|                 :|.|..|...:.:..|:||      .|.:..
Human   210 DMV-----KMNVRVMSA-----------------ILMENTPGSENHEDIELLQKLYKTGREMQER 252

  Fly   374 QMGPLIDAELERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGA 438
            .|..|:..|.|.|.   .:|.|::.||.:||..|....|:.:...
Human   253 IMDLLVVVENEDVT---VELIQVNEDLNNAILGYERFTRNQQRIL-------------------- 294

  Fly   439 ALYGAPGYPAAGGFPPAQNYPGMHSMPYGPVPNPPTSAPSQ-------APGAPGGYLGQ------ 490
                            .||.....:......|    |||||       :|..|...||:
Human   295 ----------------EQNKNQKEATNTTSEP----SAPSQDLLDLSPSPRMPRATLGELNTMNN 339

  Fly   491 ---------PQGQVPLPYQNGHAAQMNSLPAHLTQPTGTAPMPQ--------------------P 526
                     |...|....:.....|||.|....|:   ..|..|                    .
Human   340 QLSGLNFSLPSSDVTNNLKPSLHPQMNLLALENTE---IPPFAQRTSQNLTSSHAYDNFLEHSNS 401

  Fly   527 IYTQPTPVTT------QQQQQPLP-QHPQQPPQQQGQQPPQHPQNSYHIDPQSQYAQVPPAVT 582
            ::.||..:.|      .|...||| .||..  .:...|||    |.|.:   .::..:.||||
Human   402 VFLQPVSLQTIAAAPSNQSLPPLPSNHPAM--TKSDLQPP----NYYEV---MEFDPLAPAVT 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	32/154 (21%)
		SH3_STAM	235..288	CDD:212754	0/52 (0%)
		GAT	340..412	CDD:281166	19/77 (25%)
TOM1L1	NP_005477.2	VHS_Tom1	14..154	CDD:239623	31/142 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..179		7/58 (12%)
		GAT_TM1L1	199..290	CDD:260095	29/125 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..327		7/32 (22%)
		Interaction with GRB2. /evidence=ECO:0000250	392..395		0/2 (0%)
		SH3-binding. /evidence=ECO:0000250	421..425		1/3 (33%)
		Interaction with PIK3R1. /evidence=ECO:0000250	442..445		1/5 (20%)
		SH2-binding. /evidence=ECO:0000250	460..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141239
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840