DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stam and gga3b

DIOPT Version :9

Sequence 1:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_009297383.1	Gene:	gga3b / 100334661	ZFINID:	ZDB-GENE-131126-18	Length:	709	Species:	Danio rerio

Alignment Length:	698	Identity:	136/698 - (19%)
Similarity:	230/698 - (32%)	Gaps:	242/698 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FGQSSPFDADVEKATSETNTNDNWSLILDVCDKVT---TNPRLAKDCLKAVMRRMGH---TDPHV 62
            |.:....::.:.|||..||..::|..|:..||::.   ..|::|       :|.:.|   .....
Zfish     6 FPEGESLESWLNKATHPTNRQEDWEYIIGFCDQINKELEGPQIA-------VRLLVHKFCAQEWE 63

  Fly    63 VMQAITLLDALSNNCGKPLHLEVASRDFETEFRRLLA------KAQPKVSLKMRQVLKNWA---E 118
            .:||:|:|:|...|||:..|.|:|...|..|..::::      ....||..|:.::|.:|.   .
Zfish    64 ALQALTVLEACMKNCGRRFHKEIARYRFLNELIKVVSPMYMGNSISEKVKSKIIEMLYSWTVAFP 128

  Fly   119 NDYKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKAIE 183
            |:.|       |...|..|:::|....:......||:.....|.||:|..     :.:|:.|.:
Zfish   129 NEAK-------IAEAYQTLKRQGLVKSDPELTVDKTLIPSPPARPKNPVF-----DNEDMGKLL- 180

  Fly   184 LSLKENKGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEP-----RKVRALYDF 243
                                                    ||...:..||.     |.::.:...
Zfish   181 ----------------------------------------AELLRSKNPEDLQEANRLIKNMVKE 205

  Fly   244 EAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAA 308
            :.|..::||    :.|:.|::.:.|              ...:|..||         |..:..::
Zfish   206 DDARVHKLT----KRINTLEEVNNN--------------VKLLTEMLS---------QYDRERSS 243

  Fly   309 AGQRELDSAAALQQKTEAAAAAAAAQPVEIDE--SKIDRLLHLLHEANPEDPSQDSDEMLQLEQE 371
            ...|||                       |.|  .:.|:|.....:...|  ::|:|..|
Zfish   244 DADREL-----------------------IKELYERCDKLRRTAFKLATE--AEDNDSSL----- 278

  Fly   372 VHQMGPLIDA--ELERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAG 434
                |.::.|  :|.||...:.::.:..:|..:|..|        |.||.....:..|.:..|||
Zfish   279 ----GDILKANDDLSRVISCYKRIVEGQADDGEAEEL--------RPAANEACESGTGTLIDLAG 331

  Fly   435 FPGAALYGAPGYPAAGGFPPAQNYPGMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPY 499
            .      ..|..|                    |.|.||..||:.||.        |..|:.|..
Zfish   332 L------DEPSSP--------------------PPPPPPAPAPTLAPA--------PAPQISLAT 362

  Fly   500 QNGHAAQMNSLPAHLTQPTGTAPMPQPIYTQPTPVTTQQQQQPLPQHPQQPPQQQGQQPPQHPQN 564
            |.  |:.:..||          |.|:.:      ......|...|.|          :..:|..:
Zfish   363 QK--ASSIPVLP----------PPPRRL------AGAHGSQTSSPNH----------KAAEHQSS 399

  Fly   565 SYHIDPQ--SQYAQVPPAVTQIQQPQQPPAPHAYMSPQHQQAPPPQGYQPGPNLYGPNGSPAVVN 627
            ...:|.:  |.....||:|     |.:|............|||     .||.:|:|...:|:.|.
Zfish   400 LSLLDDELLSLGLNDPPSV-----PNRPKLDDLSAQWTSLQAP-----DPGLDLFGSISAPSAVF 454

  Fly   628 PQSYMSPQQQQQQHPPPHDQFSQLH----QQMAAMSMAGGPPV-GAPG 670
            |.:          |.|.....:..|    |:::.:...|...| ||.|
Zfish   455 PST----------HTPAPTSHTLTHAQGLQELSVLDFGGEKSVCGASG 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	37/158 (23%)
		SH3_STAM	235..288	CDD:212754	7/52 (13%)
		GAT	340..412	CDD:281166	15/75 (20%)
gga3b	XP_009297383.1	VHS_GGA	11..148	CDD:239624	37/150 (25%)
		PARP_reg	<133..207	CDD:280950	17/119 (14%)
		GAT_GGA3	215..301	CDD:260098	23/142 (16%)
		Alpha_adaptinC2	588..701	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840