DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and AURKB

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001271455.1	Gene:	AURKB / 9212	HGNCID:	11390	Length:	345	Species:	Homo sapiens

Alignment Length:	319	Identity:	146/319 - (45%)
Similarity:	205/319 - (64%)	Gaps:	24/319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RNHLPHLLAKVPEE--HQEPIKNMCLKMMS---------------HDAYGQPYDWSPR-----DF 53
            |...|..|:.:|:.  .:||:....|.:||               .::.|.|...:.|     ||
Human    14 RQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRRHFTIDDF 78

  Fly    54 EMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLT 118
            |:|..||:||||.||||||:.||::||:||:||.::.|..|:.|:.||||||:.|.||:||||..
Human    79 EIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 143

  Fly   119 WFHDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPEN 183
            :|:|..||||.||.|..|||:|.|:  .:..|||.|:|....::|:||.|||...|||||:||||
Human   144 YFYDRRRIYLILEYAPRGELYKELQ--KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPEN 206

  Fly   184 ILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGC 248
            :||....:||:||||||.|.|:.:|:|:|||||||||||::|..:::.||.||:|:||||.:||.
Human   207 LLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGN 271

  Fly   249 PPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKA 307
            |||||.|...||.:|.::::.:|:.:..|.::||..|||.....|:.|..|..|.||:|
Human   272 PPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRA 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	132/253 (52%)
AURKB	NP_001271455.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		2/7 (29%)
		PKc_like	71..340	CDD:304357	135/262 (52%)
		S_TKc	78..328	CDD:214567	130/251 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	LDO	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.810