DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and IPL1

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_015115.1	Gene:	IPL1 / 855892	SGDID:	S000006130	Length:	367	Species:	Saccharomyces cerevisiae

Alignment Length:	307	Identity:	132/307 - (42%)
Similarity:	193/307 - (62%)	Gaps:	11/307 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSRAKHANRNHLPHLLAKVPEEHQEPIKNMCLKMMSHDAYGQP--YDWSPRDFEMGAHLGRGKFG 65
            |:|....|:..|....:|:|    .||:......|.|:....|  ...|..|||:|..||:||||
Yeast    56 LNRLPVNNKKFLDMESSKIP----SPIRKATSSKMIHENKKLPKFKSLSLDDFELGKKLGKGKFG 116

  Fly    66 RVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLAL 130
            :||..|.|.:.|:.|:|||.|||:.|..:|:|..||:|||:.|.||::.:...:||||.|:||.:
Yeast   117 KVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLM 181

  Fly   131 EIASEGELFKHLR-GAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKL 194
            |....||::|.|| ..|   |::..::.|.||:||||:|.|..|:||||:||||||:...:.:||
Yeast   182 EYLVNGEMYKLLRLHGP---FNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKL 243

  Fly   195 ADFGWS-AHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPPFESNSTES 258
            .||||| .:.|.|:|:|:|||:|||.||||:...||.::|.|.||:|.:|.:.|.||||....::
Yeast   244 TDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDT 308

  Fly   259 TYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWV 305
            ||.:|..::|..||::|:..::||..||:.:.|.|:.|.||..|.|:
Yeast   309 TYKRIAALDIKMPSNISQDAQDLILKLLKYDPKDRMRLGDVKMHPWI 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	120/256 (47%)
IPL1	NP_015115.1	STKc_Aurora	118..356	CDD:270909	110/241 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I347
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm46627
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	LDO	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
TreeFam	0	0.000	Not matched by this tool.
	9	8.840