DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and aurkb

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_997731.2	Gene:	aurkb / 791894	ZFINID:	ZDB-GENE-020419-40	Length:	320	Species:	Danio rerio

Alignment Length:	292	Identity:	140/292 - (47%)
Similarity:	200/292 - (68%)	Gaps:	20/292 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PEEH------QEPIKNMCLKMMSHDAYGQPYDWSPRDFEMGAHLGRGKFGRVYLARERHSHYLVA 80
            |:.|      :.|:|:.. |::|.|           ||::|..||:||||.|||||||....::|
Zfish    28 PDTHAVSGPGRVPVKSNS-KVLSID-----------DFDIGRPLGKGKFGNVYLARERKLKVVIA 80

  Fly    81 MKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIASEGELFKHLRGA 145
            :||:||.::.|..|:.|:.|||||||.|:||:|||...:|||::|::|.||.|..||::|.|:..
Zfish    81 LKVLFKSQMVKEGVEHQLRREIEIQSHLRHPNILRFYNYFHDDTRVFLILEYAPRGEMYKELQRY 145

  Fly   146 PNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRT 210
            .:  ||:.|:|.|..:|::||.|||...|||||:||||:||....:||:||||||.|.|:.:|||
Zfish   146 GH--FDDQRTATYMEEVSDALQYCHEKKVIHRDIKPENLLLGYRGELKIADFGWSVHAPSLRRRT 208

  Fly   211 LCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPPFESNSTESTYSKIRRMEISYPSHLS 275
            :|||||||||||::|:|:|:.||.|.:|:||||.:||.||||:.|...||.:|.::::.:|..:|
Zfish   209 MCGTLDYLPPEMIEGHSHDEKVDLWSIGVLCYECLVGNPPFETASHAETYKRITKVDLQFPKLVS 273

  Fly   276 KGCKELIGGLLRKESKGRITLVDVMTHYWVKA 307
            :|.::||..|||.....|:.|..||.|.||||
Zfish   274 EGARDLISKLLRHSPSMRLPLRSVMEHPWVKA 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	130/253 (51%)
aurkb	NP_997731.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		2/9 (22%)
		STKc_Aurora-B_like	46..315	CDD:271019	136/273 (50%)
		S_TKc	53..303	CDD:214567	128/251 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850