Protein Alignment aurB and AURKC

DIOPT Version :10

• Sequence 1: NP_477336.1
• Gene: aurB / 34504
• FlyBaseID: FBgn0024227
• Length: 329
• Species: Drosophila melanogaster
• Sequence 2: NP_001015878.1
• Gene: AURKC / 6795
• HGNCID: 11391
• Length: 309
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 140/305 - (45%)
• Similarity: 204/305 - (66%)
• Gaps: 19/305 - (6%)

  Fly     3 LSRAKHANRNHLPHLLAKVPEEHQEPIKNMCLKMMSHDAYGQPYDWSPRDFEMGAHLGRGKFGRV 67
            |.:|:.|...     ||...:..|:| .:..::.::.|           |||:|..||:||||.|
Human    10 LGKAQPAGEE-----LATANQTAQQP-SSPAMRRLTVD-----------DFEIGRPLGKGKFGNV 57

  Fly    68 YLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEI 132
            ||||.:.||::||:||:||.::.|..::.|:.||||||:.|:||:||||..:|||..|:||.||.
Human    58 YLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEY 122

  Fly   133 ASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADF 197
            |..|||:|.|:  .:.:.||.|:|....::|:||.|||...|||||:||||:||....::|:|||
Human   123 APRGELYKELQ--KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADF 185

  Fly   198 GWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPPFESNSTESTYSK 262
            |||.|||:.:|:|:|||||||||||::|.:||:.||.||:|:||||.:||.|||||.|...||.:
Human   186 GWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRR 250

  Fly   263 IRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKA 307
            |.::::.:|..:..|.::||..|||.:...|:.|..::.|.||:|
Human   251 ILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQA 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	130/253 (51%)
AURKC	NP_001015878.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		7/28 (25%)
		STKc_Aurora-B_like	36..305	CDD:271019	133/273 (49%)
		Interaction with BIRC5. /evidence=ECO:0000269|PubMed:27332895	292..309		3/4 (75%)