DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and AURKA

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	XP_016883523.1	Gene:	AURKA / 6790	HGNCID:	11393	Length:	437	Species:	Homo sapiens

Alignment Length:	335	Identity:	145/335 - (43%)
Similarity:	217/335 - (64%)	Gaps:	20/335 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RAKHANRNHLPHLLAK--------------VPEEHQEPIKNMCLKMMSHDAYGQPYDWSPRDFEM 55
            :.|......:||.:::              .||.:  |.:.:..|..:.::  :...|:..|||:
Human   109 KQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENN--PEEELASKQKNEES--KKRQWALEDFEI 169

  Fly    56 GAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWF 120
            |..||:||||.||||||:.|.:::|:||:||.:|.|..|:.|:.||:||||.|:||:||||..:|
Human   170 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF 234

  Fly   121 HDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENIL 185
            ||.:|:||.||.|..|.:::.|:..  .:|||.|:|.|..::||||:|||...|||||:||||:|
Human   235 HDATRVYLILEYAPLGTVYRELQKL--SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 297

  Fly   186 LTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPP 250
            |.|..:||:||||||.|.|:::|.|||||||||||||::|..:|:.||.|.||:|||||:||.||
Human   298 LGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP 362

  Fly   251 FESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKAGMAERELQ 315
            ||:|:.:.||.:|.|:|.::|..:::|.::||..||:.....|..|.:|:.|.|:.|..::....
Human   363 FEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNC 427

  Fly   316 LQKRERGKEN 325
            ..|....|::
Human   428 QNKESASKQS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	134/253 (53%)
AURKA	XP_016883523.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820