Protein Alignment aurB and RPS6KB1

DIOPT Version :10

• Sequence 1: NP_477336.1
• Gene: aurB / 34504
• FlyBaseID: FBgn0024227
• Length: 329
• Species: Drosophila melanogaster
• Sequence 2: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 89/295 - (30%)
• Similarity: 145/295 - (49%)
• Gaps: 49/295 - (16%)

  Fly    37 MSHDAYGQPYDWS----------------------PRDFEMGAHLGRGKFGRVYLARE---RHSH 76
            |.|...| ||:..                      |..||:...||:|.:|:|:..|:   .::.
Human    54 MDHGGVG-PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTG 117

  Fly    77 YLVAMKVMFKEELRKGC-------VQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIAS 134
            .:.||||:.|..:.:..       .:|.:|.|:      |||.|:.|:..|....::||.||..|
Human   118 KIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV------KHPFIVDLIYAFQTGGKLYLILEYLS 176

  Fly   135 EGELFKHL--RGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADF 197
            .||||..|  .|.    |.|..:..|..:::.||.:.|...:|:||||||||:|.....:||.||
Human   177 GGELFMQLEREGI----FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDF 237

  Fly   198 GW---SAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPPFESNSTEST 259
            |.   |.| ......|.|||::|:.||::..:.::.:||.|.||.|.|:.:.|.|||...:.:.|
Human   238 GLCKESIH-DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT 301

  Fly   260 YSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRI 294
            ..||.:.:::.|.:|::..::|:..||::.:..|:
Human   302 IDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRL 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	83/258 (32%)
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		89/295 (30%)
		TOS motif	28..32
		STKc_p70S6K	94..416	CDD:270736	81/254 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399
		Autoinhibitory domain	424..525