DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and aurkb

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	XP_012809281.1	Gene:	aurkb / 549613	XenbaseID:	XB-GENE-1019626	Length:	370	Species:	Xenopus tropicalis

Alignment Length:	256	Identity:	137/256 - (53%)
Similarity:	187/256 - (73%)	Gaps:	2/256 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DFEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRL 116
            ||::|..||:||||.|||||::.:.:::|:||:||.:|.|..|:.|:.|||||||.|:||:|||:
Frog   102 DFDIGRPLGKGKFGNVYLARDKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRM 166

  Fly   117 LTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKP 181
            ..:|||..||||.||.|..|||:|.|:  .:.||||.|||.:..::|:||.|||...|||||:||
Frog   167 YNYFHDRKRIYLMLEFAPRGELYKELQ--KHGRFDEQRSATFMEELADALQYCHERKVIHRDIKP 229

  Fly   182 ENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVV 246
            ||:|:....:||:||||||.|.|:.:|||:|||||||||||::|.::|:.||.||.|:||:||:|
Frog   230 ENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCFEFLV 294

  Fly   247 GCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKA 307
            |.|||:|.|...|:.:|..:::.:|..||.|.|:||..|||.....|:.|..||.|.||||
Frog   295 GMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKA 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	134/253 (53%)
aurkb	XP_012809281.1	STKc_Aurora-B_like	96..365	CDD:271019	137/256 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24350
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020