DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and Aurka

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_695208.2	Gene:	Aurka / 261730	RGDID:	628895	Length:	397	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	137/264 - (51%)
Similarity:	198/264 - (75%)	Gaps:	2/264 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 WSPRDFEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPH 112
            |:..||::|..||:||||.||||||:.|.:::|:||:||.:|.|..|:.|:.||:||||.|:||:
  Rat   121 WTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPN 185

  Fly   113 ILRLLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHR 177
            ||||..:|||.:|:||.||.|..|.:::.|:..  .:|||.|:|.|..::||||:|||...||||
  Rat   186 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKL--SKFDEQRTATYITELANALSYCHSKRVIHR 248

  Fly   178 DLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCY 242
            |:||||:||.|..:||:||||||.|.|:::|.|||||||||||||::|..:|:.||.|.||:|||
  Rat   249 DIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCY 313

  Fly   243 EFVVGCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKA 307
            ||:||.||||:::.:.||.:|.|:|.::|..:::|.::||..||:..|..|:||.:|:.|.|:||
  Rat   314 EFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNSSQRLTLAEVLEHPWIKA 378

  Fly   308 GMAE 311
            ..::
  Rat   379 NSSK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	134/253 (53%)
Aurka	NP_695208.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118
		STKc_Aurora-A	120..376	CDD:271018	134/256 (52%)
		Activation segment. /evidence=ECO:0000250\|UniProtKB:O14965	273..286		7/12 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..397		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820