DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and Aurkb

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_035626.1	Gene:	Aurkb / 20877	MGIID:	107168	Length:	345	Species:	Mus musculus

Alignment Length:	264	Identity:	132/264 - (50%)
Similarity:	190/264 - (71%)	Gaps:	4/264 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QPYDWSPRDFEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRL 108
            ||:  :..:||:|..||:||||.||||||:.|.::||:|::||.::.|..|:.|:.||||||:.|
Mouse    75 QPF--TIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHL 137

  Fly   109 KHPHILRLLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNN 173
            |||:||:|..:|:|:.||||.||.|..|||:|.|:  .:..|||.|:|....::::||.|||...
Mouse   138 KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQ--KSRTFDEQRTATIMEELSDALTYCHKKK 200

  Fly   174 VIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLG 238
            |||||:||||:||....:||:||||||.|.|:.:|:|:|||||||||||::|..:::.||.||:|
Mouse   201 VIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIG 265

  Fly   239 ILCYEFVVGCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHY 303
            :||||.:||.|||||.|...||.:|.::::.:||.:..|.::||..||:.....|:.|.:|..|.
Mouse   266 VLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHP 330

  Fly   304 WVKA 307
            ||:|
Mouse   331 WVRA 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	128/253 (51%)
Aurkb	NP_035626.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..77		1/1 (100%)
		PKc_like	77..344	CDD:304357	130/262 (50%)
		S_TKc	82..332	CDD:214567	127/251 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	LDO	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.810