DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aurB and Aurkc

DIOPT Version :9

Sequence 1:	NP_477336.1	Gene:	aurB / 34504	FlyBaseID:	FBgn0024227	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001074434.1	Gene:	Aurkc / 20871	MGIID:	1321119	Length:	315	Species:	Mus musculus

Alignment Length:	255	Identity:	128/255 - (50%)
Similarity:	188/255 - (73%)	Gaps:	2/255 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DFEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRL 116
            |||:|..|||||||||||||.:.:|::||:||:||.|:.|..::.|:.||:|||:.|:|.:||||
Mouse    54 DFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRL 118

  Fly   117 LTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKP 181
            ..:|:|::||||.||.|..|||:|.|:  .:.:.|:.|:|....::::||.|||...|||||:||
Mouse   119 YNYFYDDTRIYLILEYAPGGELYKELQ--RHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKP 181

  Fly   182 ENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVV 246
            ||:||....::|::|||||.|||:.:|:|:|||||||||||:....|::.||.||:|:||||.:|
Mouse   182 ENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLV 246

  Fly   247 GCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVK 306
            |.|||||:::..||.:||:::..:||.:..|.::||..|||.....|::|..|:.|.||:
Mouse   247 GKPPFESSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVR 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	127/253 (50%)
Aurkc	NP_001074434.1	PKc_like	48..314	CDD:304357	128/255 (50%)
Aurkc	NP_001074434.1	S_TKc	55..305	CDD:214567	125/251 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68302
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2391
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850