DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnz1 and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	252	Identity:	66/252 - (26%)
Similarity:	110/252 - (43%)	Gaps:	35/252 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CGIACLVVTYGAVLYADYVVIRWIILTTMPGSLWMSFH-----------VVLFNTVVFLLAMS-H 60
            ||...::..:|.|    :.:...:||||.  .|:..|.           :.:...::|...|| .
Human    81 CGGRLMLAGHGGV----FALTLLLILTTT--GLFFVFDCPYLARKLTLAIPIIAAILFFFVMSCL 139

  Fly    61 SKAVFSDPGTVP----LPANRLDFSDLHTTNKN--NPPPG------NGHSSEWTVCTRCETYRPP 113
            .:..|:|||.:|    ..|..|: ..:..|..:  .|||.      ||...:...|..|:.:|||
Human   140 LQTSFTDPGILPRATVCEAAALE-KQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPP 203

  Fly   114 RAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLSLYSIALIVGSWVWPCEECSQ 178
            |..||.:|..|:.|.||||||:.||||.||.::|..|::.::.|:.:..|.:|.......:  ..
Human   204 RTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLRAQ--GS 266

  Fly   179 NVIETQLRMIHSVILMLVSALFGLFVTAIMVDQLHAILYDETAVEAIQQKGTYRPNR 235
            |.:.| |:...:.:|.||...|.:: :.:.:...|..|...........||::...|
Human   267 NFLST-LKETPASVLELVICFFSIW-SILGLSGFHTYLVASNLTTNEDIKGSWSSKR 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	37/130 (28%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		zf-DHHC	191..314	CDD:279823	37/126 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740