DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and Zdhhc1

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_001365935.1	Gene:	Zdhhc1 / 70796	MGIID:	1918046	Length:	484	Species:	Mus musculus

Alignment Length:	248	Identity:	70/248 - (28%)
Similarity:	106/248 - (42%)	Gaps:	54/248 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VIRWIILTTMPGSLWMSFHVVLFNTVVFLL-------AMSHSKAVFSDPGTVPLPANRLDFSDLH 84
            ::.|:        |::.|.|:.|..:|.||       ..:...|:|:....|.|.|..:|.:|.:
Mouse    50 IVAWL--------LYLFFAVIGFGVLVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADAN 106

  Fly    85 TTNKNNPPP-------GNGHSSEWTVCTRCETYRPPRAHHCRICKRCIRRMDHHCPWINNCVGER 142
            ..:|:...|       .:.|..|...|..|:.....|:.||..|.:|:...||||.|:|||||||
Mouse   107 VRDKSYSGPLPIFNRSQHAHVIEDLHCNLCDVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGER 171

  Fly   143 NQKYFL----QFLIYVALLSLYSIALIVGSWVWPCE-------ECSQN------------VIETQ 184
            |.:.||    ..|:.|.||.|.:..:.|..:|.|..       |..:|            .:|||
Mouse   172 NYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNQHFEVLKNHTDVWFVFLPAAPVETQ 236

  Fly   185 LRMIHSVILMLVSALFGLFVTAIMVDQL--HAIL--YDETAVEAIQQKGTYRP 233
            ...|.::..:|:  |.||..||::...|  |..|  :..|..|.|.|   :||
Mouse   237 APAILALAALLI--LLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQ---HRP 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	50/157 (32%)
Zdhhc1	NP_001365935.1	Mediates interaction with STING1. /evidence=ECO:0000250\|UniProtKB:Q8WTX9	1..268		63/227 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		DHHC	126..281	CDD:396215	50/156 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..415
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840