DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	248	Identity:	69/248 - (27%)
Similarity:	112/248 - (45%)	Gaps:	49/248 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MSFHVVLFNTVVFLLAMSHSKAVFSDPGTVPL-PANRLDFSDLHTTNKNNPPPGNGH-------- 97
            |::| :||...|:    |:.|.:|    |:|: |:.....|..........|.|..|
Mouse    56 MAYH-LLFAMFVW----SYWKTIF----TLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAA 111

  Fly    98 ----------SSEWTVCTRCETYRPPRAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLI 152
                      |.....|.||:..:|.|.|||.:|.:||.:|||||||:|||||..|.|:||.||.
Mouse   112 KDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLA 176

  Fly   153 YVALLSLYSIALIVGSWV--WPCEECSQNVIETQLRMIHSVILMLVSALFGLFVTAIMVDQLHAI 215
            |..|..|:..|..:..::  |     :..:.:||.: .|.:.|...:|:|.:.::::.......:
Mouse   177 YSLLYCLFIAATDLQYFIRFW-----TNGLPDTQAK-FHIMFLFFAAAMFSVSLSSLFGYHCWLV 235

  Fly   216 LYDETAVEAIQ----QKGTYRPNRRKYQL-----LADVFGRGHPALWLLPCTS 259
            ..:::.:||.:    :.||   ::..:.|     :..||| .....||||..|
Mouse   236 SKNKSTLEAFRNPVFRHGT---DKNGFSLGFSKNMRQVFG-DEKKYWLLPVFS 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	44/154 (29%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	42/126 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848322
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750