DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	312	Identity:	78/312 - (25%)
Similarity:	125/312 - (40%)	Gaps:	76/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CLVVT--------------YGAVLYAD---------YVVIRWIIL--TTMPGS-LWMSFHVVLFN 50
            ||:||              |..::|..         ::.:.|.||  ..:.|: .:.||   :|:
Human   322 CLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSF---IFS 383

  Fly    51 TVVFLLAMSHSKAVFSDPGTVPL--PANRLDFSDLHTTNKNNPPPGNGHSSEWTVCTRCETYRPP 113
            .|.||.....:.|  :|||....  ...:::...|..|         |.....|.||.|...:|.
Human   384 IVAFLYFFYKTWA--TDPGFTKASEEEKKVNIITLAET---------GSLDFRTFCTSCLIRKPL 437

  Fly   114 RAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLSLYSIALIVGSWVWPCEECSQ 178
            |:.||.:|..|:.|.|.||.|...|:|..|..|::.||.:::::..:   :|.||:::....|:.
Human   438 RSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGW---IIYGSFIYLSSHCAT 499

  Fly   179 NVIE----TQLRMIHS------VILMLVSALFGLFVTAIMVDQLHAILY-DETAVEAI------- 225
            ...|    |.|..|.:      .||||.:..|. :.|.::::||..|.: ..|:.|.|
Human   500 TFKEDGLWTYLNQIVACSPWVLYILMLATFHFS-WSTFLLLNQLFQIAFLGLTSHERISLQKQSK 563

  Fly   226 QQKGTYRPNRRKYQL-----LAD-----VFGRGHPAL--WLLPCTSLNHASR 265
            ..|.|....:..|.|     |||     .||...|.:  |....|.:.|.:|
Human   564 HMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVFHPAR 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	41/148 (28%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	41/139 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810