Protein Alignment Dnz1 and ZDHHC2

DIOPT Version :10

• Sequence 1: NP_477449.1
• Gene: Dnz1 / 34503
• FlyBaseID: FBgn0027453
• Length: 276
• Species: Drosophila melanogaster
• Sequence 2: XP_011542846.1
• Gene: ZDHHC2 / 51201
• HGNCID: 18469
• Length: 412
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 77/283 - (27%)
• Similarity: 120/283 - (42%)
• Gaps: 56/283 - (19%)

  Fly    16 TYGAVLYADYVVIRWII---LTTMPGSLWMSF----HVVLFNTVVFLLAMSHSKAVFSDPGTVPL 73
            |.|...|.:..||...|   |:.:|..|..:|    .|:|.|   :|...:.|   |...|....
Human    65 TLGKEFYPEMAVIVPEILKALSCVPDGLSSTFCNVCLVILEN---YLYITNES---FKRNGATGF 123

  Fly    74 PANRLDFSDLHTTNKN---NPPPGNGH------------------SSEWTVCTRCETYRPPRAHH 117
            ....:.| .|....|:   ..|.|..|                  |.....|.||:..:|.|.||
Human   124 EHETIKF-HLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHH 187

  Fly   118 CRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLSLYSIALIVGSWV--WPCEECSQNV 180
            |.:|.:||.:|||||||:|||||..|.|:||.||.|..|..|:..|..:..::  |     :..:
Human   188 CSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIKFW-----TNGL 247

  Fly   181 IETQLRMIHSVILMLVSALFGLFVTAIMVDQLHAILYDETAVEAIQ----QKGTYRPNRRKYQL- 240
            .:||.: .|.:.|...:|:|.:.::::.......:..:::.:||.:    :.||   ::..:.|
Human   248 PDTQAK-FHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGT---DKNGFSLG 308

  Fly   241 ----LADVFGRGHPALWLLPCTS 259
                :..||| .....||||..|
Human   309 FSKNMRQVFG-DEKKYWLLPIFS 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	44/154 (29%)
ZDHHC2	XP_011542846.1	DHHC	172..293	CDD:396215	42/126 (33%)