DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and ZDHHC8

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_001171953.1	Gene:	ZDHHC8 / 29801	HGNCID:	18474	Length:	778	Species:	Homo sapiens

Alignment Length:	250	Identity:	72/250 - (28%)
Similarity:	102/250 - (40%)	Gaps:	48/250 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 WIILTTMPGSLWMSFHVVLFNTVVFLLAMSH-SKAVFSDPGTVPLPANRLDFSD-----LHTTNK 88
            |:.....|.       |.::|.::||..::: |.|.|.|||..|......|..|     |:   |
Human    38 WLTRAVSPA-------VPVYNGIIFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLY---K 92

  Fly    89 NNPPPGNGHSSEWTVCTRCETYRPPRAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIY 153
            |....|.....:|  |..|..|||||..||.:|..|:...||||||:|||:|.||.:||..||:
Human    93 NVDVRGIQVRMKW--CATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLL- 154

  Fly   154 VALLSLYSIALIVGSWVWPCEECSQNVIETQLRMIHSVILMLVSALFGL-FVTAIMVDQLHAILY 217
              .||.:.:.::....|:......      .|...|:.|.|.|..:.|| |:..|.:...|.:|.
Human   155 --SLSAHMVGVVAFGLVYVLNHAE------GLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLV 211

  Fly   218 DETAVEAIQQKGTYRPNRRKYQLLADVFGRGHPALWLLPCTSLNH------ASRY 266
            ........|..|.:|..       .:.|.||       .|.::.|      |.||
Human   212 TRGRTTNEQVTGKFRGG-------VNPFTRG-------CCGNVEHVLCSPLAPRY 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	43/131 (33%)
ZDHHC8	NP_001171953.1	DHHC	99..224	CDD:366691	43/135 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..352
		PHA03247	<333..771	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810