DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and dhhc-14

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_001024514.2	Gene:	dhhc-14 / 181109	WormBaseID:	WBGene00044071	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	278	Identity:	70/278 - (25%)
Similarity:	114/278 - (41%)	Gaps:	49/278 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFIR----DPCGIACLVVTYGAVLYADYVVIRWIILTTMPGSLWMSFHV-----VLFNTVVFLL 56
            ||.||    ||        ||..:.|.  |.|...||..:..|.:..::|     :||...|..|
Worm   307 MVLIRFDYHDP--------TYKLLPYG--VTIAEAILMVLSWSAYAHWYVPWWAQMLFVLSVLAL 361

  Fly    57 AMSHSKAVFSDPGTVPLPANRLDFSDLHTTNKNNPPPGNGHSSEWTVCTRCETYRPPRAHHCRIC 121
            |.:..:....|||.|....|      .|....|....|..|..::  |..|...:.....||.:|
Worm   362 AFTLFRIGTLDPGVVRAAKN------CHQLFVNEAEAGIQHQQKY--CFTCFIRKMDHTKHCAVC 418

  Fly   122 KRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLS-LYSIALIVGSWVWPCEECSQNVIETQL 185
            ..|:...||||||:|:||..||.:.|:.|:|.|::.| :|.:|....:.:...:...:..:||..
Worm   419 GFCVNNFDHHCPWLNSCVTRRNMREFIMFVISVSVSSAIYCMATSHYALLQIEDHGLEEFLETDA 483

  Fly   186 RMIHSVILMLVSALFGLFVTAIMVDQLHAILYDETAVEAIQQKGT----------------YRP- 233
            .::.::||   ||:..|.:..:...|::.|....|..:.|:.:..                ::|
Worm   484 FLMITIIL---SAMHALMLAVLFCVQMNQISQGVTTNDRIKARRAGHAHSHSGSTDYNVIHHKPS 545

  Fly   234 -NRRKYQLLADVFGRGHP 250
             ::|.:.||......|.|
Worm   546 ISKRCHNLLEFFSSNGDP 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	36/131 (27%)
dhhc-14	NP_001024514.2	ANK	19..143	CDD:238125
		Ank_2	30..120	CDD:289560
		ANK repeat	55..87	CDD:293786
		ANK repeat	89..120	CDD:293786
		Ank_2	94..222	CDD:289560
		ANK	117..244	CDD:238125
		ANK repeat	190..222	CDD:293786
		PulO	<261..>367	CDD:224900	20/69 (29%)
		zf-DHHC	394..521	CDD:279823	35/131 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910