DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and ZDHHC19

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_001034706.1	Gene:	ZDHHC19 / 131540	HGNCID:	20713	Length:	309	Species:	Homo sapiens

Alignment Length:	266	Identity:	69/266 - (25%)
Similarity:	107/266 - (40%)	Gaps:	65/266 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVVTYGAVLYADYVVIRWI------ILTTMPGSLWMSFHVVLFNTVVFLLAMSHSKAVFSDPGTV 71
            |:|.:..:.:|  ...||:      ....:.|||:    |:.|.::|.|        .|||||.:
Human    37 LLVFFSGLFFA--FPCRWLAQNGEWAFPVITGSLF----VLTFFSLVSL--------NFSDPGIL 87

  Fly    72 PLPANRLDFSDLHTTNKNNPPPGNGHSSEWTVCTRCETYRPPRAHHCRICKRCIRRMDHHCPWIN 136
            ...:.......:|....|:    .....:|  |.:|..:||||.:||..|..|:...||||.|:|
Human    88 HQGSAEQGPLTVHVVWVNH----GAFRLQW--CPKCCFHRPPRTYHCPWCNICVEDFDHHCKWVN 146

  Fly   137 NCVGERNQKYFLQFLIYVALLSLYSIALIVGSWVWPCEECSQNVIETQLRMIH--------SVIL 193
            ||:|.||.::   |::.|..|.|||.|::|...::            .:|..|        ..|:
Human   147 NCIGHRNFRF---FMLLVLSLCLYSGAMLVTCLIF------------LVRTTHLPFSTDKAIAIV 196

  Fly   194 MLVSALFGLFV---TAIMVDQLHAILYDETAVEAIQQKGTYRPNRRKYQLLADVFGRGHPALWLL 255
            :.|||. ||.|   ..:::..|.....|.|.....:....|.|           |.:|..:.|.|
Human   197 VAVSAA-GLLVPLSLLLLIQALSVSSADRTYKGKCRHLQGYNP-----------FDQGCASNWYL 249

  Fly   256 P-CTSL 260
            . |..|
Human   250 TICAPL 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	42/141 (30%)
ZDHHC19	NP_001034706.1	DHHC	109..>181	CDD:366691	30/88 (34%)
ZDHHC19	NP_001034706.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..309
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810