DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dnz1 and zdhhc13

DIOPT Version :9

Sequence 1:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	XP_002942880.3	Gene:	zdhhc13 / 100493145	XenbaseID:	XB-GENE-997024	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	331	Identity:	74/331 - (22%)
Similarity:	118/331 - (35%)	Gaps:	108/331 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GIACLVVTYGAVLYADYVV----------------IRWIILT----TMPGSLWMSFHVVLFNTVV 53
            |....:||.|:.|:|...:                |.|:.||    .:||...::|.:....:::
Frog   311 GTLLALVTAGSQLFARRFIGCKSQRSLPAIIFSCCIFWMFLTWFIYFLPGLARVAFQLPFIISML 375

  Fly    54 FLLAMSHSKAVFSDPGTVPLPANRLDFSDLHTTNKNNPPPGNGHSSEWTV--------------C 104
            .|....: |...:|||.:                     ..:...|..|:              |
Frog   376 LLFYFFY-KTWCTDPGYI---------------------KSSEEESRQTIITLAEAGCLDARLFC 418

  Fly   105 TRCETYRPPRAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLSLYSIALIVGSW 169
            |.|...:|.|:.||..|..|:.|.|.||.|...|:|..||.:|:.||..:|         :||:|
Frog   419 TSCLVKKPLRSMHCHACNSCVARFDQHCVWTGQCIGAGNQHFFVLFLASLA---------VVGNW 474

  Fly   170 ------VWPCEEC-----SQNVIETQLRMIHS-----VILMLVSALFGLFVTAIMVDQLHAILY- 217
                  |:..:.|     ...:..|..::::.     .|..|||| |.::.|.:::.||..|.:
Frog   475 MIYATSVYWSDHCGMGSRKDGIWATLSQIVNCSPWVLYIFCLVSA-FTVWATLMLLVQLFQISFL 538

  Fly   218 DETAVEAIQQKGTYRP------------NRRKYQLLADVFG-------RGHPALW------LLPC 257
            ..|..|.|..:...|.            ||...|.|||.|.       :..|..|      .:|.
Frog   539 GLTTQERISLQVQNRHLKHQVSLRRTPFNRGCLQNLADFFHCQCFGLIKSQPIDWTKQYHGAIPP 603

  Fly   258 TSLNHA 263
            :.:.||
Frog   604 SRMRHA 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	43/161 (27%)
zdhhc13	XP_002942880.3	Ank_2	46..136	CDD:372319
		ANK repeat	71..102	CDD:293786
		PHA03095	82..>246	CDD:222980
		ANK repeat	104..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK repeat	171..237	CDD:293786
		DHHC	327..>549	CDD:388695	55/253 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910