DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-3 and smyd4

DIOPT Version :9

Sequence 1:	NP_001260366.1	Gene:	SmydA-3 / 34502	FlyBaseID:	FBgn0262599	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001070062.1	Gene:	smyd4 / 767654	ZFINID:	ZDB-GENE-060929-248	Length:	753	Species:	Danio rerio

Alignment Length:	499	Identity:	115/499 - (23%)
Similarity:	172/499 - (34%)	Gaps:	129/499 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QWSPVCGRYLVAKGAIRGHGLLIEELPFAVGPKCNGPVVCLG---------CYEPNPDPEEELCS 70
            ||....|..|:|.|.: ||      |...|..|.....|.:|         .|:.:...:..|..
Zfish   282 QWECPVGADLLAIGVL-GH------LALRVVLKAGQTEVQMGIKNTKDHVTTYKNDSPVQLSLGG 339

  Fly    71 ECGWPLCVECAQQADNAHFRLECSQLKDARARFFRLPSGSRHCPQLDCIM--PLRVLLAKEAN-- 131
            :||        :..|:.    :|.........:..||..::|.|....:|  .:.|:..|...
Zfish   340 DCG--------KSLDHT----DCFHGSSYMGIYSLLPHVAQHSPASRFLMAITMAVIYGKLQGGP 392

  Fly   132 -PERWDNEVAPMEHHKEERQRDADVWHADRVNI-AQYLRGPCQL--------ANRFSEELIMQVV 186
             |.:|.:       .|:|..:.:  |..:...: |..||...||        |.|..||..|.|.
Zfish   393 PPNKWMS-------FKDEGVKAS--WQPEMSMLGATALRHMMQLRCNAQAITAVRVKEESGMAVQ 448

  Fly   187 GVLEVNAFEARSPKGYPLRCLFPYTGILAHNCVPNTSRSI--------------------YPS-- 229
            ...|:....|          :||...:|.|:|.||||.|.                    :|.
Zfish   449 SSSEIRIATA----------IFPVLSLLNHSCSPNTSISFTTGFQPDPHNQLGCSEGHFDHPKGS 503

  Fly   230 -EGYKIRLRAMVDLEEGQPLHHSYTYTLDG-------TAQRQKHLKQGKFFTCQCERCLDPTELG 286
             .|..:.:||..||..||.:.|.|     |       ..:||:.|.:..||.|.|:.|......|
Zfish   504 RSGVTVTVRASKDLTAGQEILHCY-----GPHRSRMEVKERQRLLLEQYFFQCVCQACQRDLSEG 563

  Fly   287 T-----HFS-SLKCGQCAEGFQVPRQPTEPDT-SWNCANCGSDTSNADALAMLQSLQSEVNAVQA 344
            :     |.: .:||.:|.:..|   ..|:..| ||  ::||...|:||....||..|..::....
Zfish   564 SPNAKEHTAPGMKCVKCGKPLQ---SHTDGYTCSW--SSCGHQISSADVQNRLQGFQLLLDEAVH 623

  Fly   345 LPMAAKRLEEIERLLR----KYKSLLHPLHFIATGLRQLLIEMYGRVQGY---------EMVQLP 396
            | |...||.|...:|:    :..|:|...|.....|...|..:|.....:         .:|.:.
Zfish   624 L-MEQDRLNEALHILQSAFSQANSILTETHPFQGELADALARLYASTGEWSLAASHLKRSLVAIQ 687

  Fly   397 DHQLERKAELCRQVLRVLNTFEPGLSRT-------RAMNLYELH 433
            ....|...||.||:.::......|....       ||..|..||
Zfish   688 AQFGEDSIELGRQLFKLAQLHFNGRDGVASLSVIPRARRLLSLH 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-3	NP_001260366.1	SET	<207..252	CDD:250181	19/67 (28%)
smyd4	NP_001070062.1	TPR_11	68..134	CDD:290150
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..134	CDD:276809
		zf-MYND	246..285	CDD:280009	2/2 (100%)
		SET	<456..532	CDD:214614	22/90 (24%)
		T6SS_VasJ	<603..679	CDD:299836	18/76 (24%)
		TPR_12	615..683	CDD:290160	13/68 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810