back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-3 and SMYD3

DIOPT Version :9

Sequence 1:	NP_001260366.1	Gene:	SmydA-3 / 34502	FlyBaseID:	FBgn0262599	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001161212.1	Gene:	SMYD3 / 64754	HGNCID:	15513	Length:	428	Species:	Homo sapiens

Alignment Length:	513	Identity:	114/513 - (22%)
Similarity:	175/513 - (34%)	Gaps:	165/513 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RYLVAKGAIRGHGLLI------EELPFAVGP----KCNGP--VVCLGCYEPNPDPEEEL--CSEC 72
            ::..||   ||:||..      .||.|...|    .|.|.  |||..|..    .:|:|  ||:|
Human     8 KFATAK---RGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLL----GKEKLMRCSQC 65

  Fly    73 G-WPLC-VECAQQADNAHFRLECSQLKDARARF------------FRLPSGS-RHCPQLDCIMPL 122
            . ...| .:|.::|...|.| ||..||..:.|:            |:|..|: ....:|.....|
Human    66 RVAKYCSAKCQKKAWPDHKR-ECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDL 129

  Fly   123 RVLLAK--EANPERWDNEVAPMEHHKEERQRDA-------DVWHADRVNIAQYLRGPCQLANRFS 178
            ...:.|  |...|.....|...:|...|..:||       |::.|    .|:.:.....:.|  :
Human   130 ESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEA----FAKVICNSFTICN--A 188

  Fly   179 EELIMQVVGVLEVNAFEARSPKGYPLRCLFPYTGILAHNCVPNTSRSIYPSEGYKIRLRAMVDLE 243
            |   ||.|||                 .|:|...:|.|:|.||.|   ....|..:.|||:.|:|
Human   189 E---MQEVGV-----------------GLYPSISLLNHSCDPNCS---IVFNGPHLLLRAVRDIE 230

  Fly   244 EGQPLHHSYTYTLDGTAQRQKHLKQGKFFTCQCERCLDPTELGTHFSSLKCGQCAEGFQVPRQPT 308
            .|:.|...|...|..:.:|:|.|:....|.|.|.||                          |..
Human   231 VGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRC--------------------------QTQ 269

  Fly   309 EPDTSWNCANCGSDTSNADALAMLQSLQSEVNAVQALPMAAKRLEEIERLLRKYKSLLHPLHFIA 373
            :.|              ||.|...:.:..||.         :.|::||.|...:|
Human   270 DKD--------------ADMLTGDEQVWKEVQ---------ESLKKIEELKAHWK---------- 301

  Fly   374 TGLRQLLIEMYGRVQGYEMVQLPD---HQ---LERKAELC-------------RQVLRVLNTFEP 419
               .:.::.|...:......:|||   :|   |:...:.|             .:.:.....|.|
Human   302 ---WEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFP 363

  Fly   420 GLSRTRAMNL-----YELHVPLVLLA----KSGFIAGKLKGGELRARLVDAIDLLKEC 468
            |....|.:.:     .:||..:...|    :..|...::..|...:.:.|.|.||:||
Human   364 GSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEEC 421

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.