DRSC/TRiP Functional Genomics Resources

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Protein Alignment SmydA-3 and SMYD4

DIOPT Version :10

Sequence 1:NP_609464.1 Gene:SmydA-3 / 34502 FlyBaseID:FBgn0262599 Length:507 Species:Drosophila melanogaster
Sequence 2:NP_443160.2 Gene:SMYD4 / 114826 HGNCID:21067 Length:804 Species:Homo sapiens


Alignment Length:501 Identity:110/501 - (21%)
Similarity:163/501 - (32%) Gaps:178/501 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 PVCGRYLVAKGAIRGHGLLIEELPF--AVGP-----------------KCNGPVVCLGCYEPN-- 61
            |:.||.|||...|....||::|..|  .:.|                 ..||.:.|..|.:..  
Human   241 PLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLA 305

  Fly    62 --PDPEEELCSECGW-PLC-VECAQQADNAHFRLECS----------------------QLKDAR 100
              |      |..|.: ..| .||.|||...:.|.||.                      ..:|.|
Human   306 TVP------CDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVR 364

  Fly   101 ARFFRLPSGSRHCPQL---DCIMPLRVLLAKEANPERWDNEVAPMEHHKEERQRDADV------- 155
            ....:|      |.::   |..:|       |:|     |:|..:.:...|.:::.::       
Human   365 KIITKL------CDKISNKDICLP-------ESN-----NQVKTLNYGLGESEKNGNIVETPIPG 411

  Fly   156 -----WHADRVNIA--------------QYLRGPC-------------------------QLANR 176
                 .:.:..|..              ::|...|                         ||...
Human   412 CDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAA 476

  Fly   177 FSEELIMQVV--GV--------LEVNA-----FEARSPKG------YPLRC---LFPYTGILAHN 217
            .:.||...|.  ||        |:.||     .:...|||      ..:|.   :||...:|.|:
Human   477 VTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHS 541

  Fly   218 CVPNTSRSIYPSEGYKIRLRAMVDLEEGQPLHHSY--TYTLDGTAQRQKHLKQGKFFTCQCERCL 280
            |.||||.|...:..   .:||...:.:||.:.|.|  ..:..|.|:||:.|:...||.|.|..| 
Human   542 CSPNTSVSFISTVA---TIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC- 602

  Fly   281 DPTE-----LGTHFSSLKCGQCAEGFQVPRQPTEPDTSWNCA--NCGSDTSNADAL-AMLQSLQS 337
             .||     .|..:.:..|..|.       .|.:.|....|.  :|.....:.|.| :.||.||.
Human   603 -QTEAHRMAAGPRWEAFCCNSCG-------APMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQ 659

  Fly   338 EVNAVQALPMAAKRLEEIERL---LRKYKSLLHPLHF----IATGL 376
            :|...|.|....:....::||   .|..:|.|...|.    ||.||
Human   660 QVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGL 705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmydA-3NP_609464.1 SET_SMYD <192..279 CDD:380997 31/102 (30%)
SMYD4NP_443160.2 NlpI <66..>171 CDD:443815
TPR repeat 68..96 CDD:276809
TPR repeat 101..135 CDD:276809
TPR repeat 143..171 CDD:276809
SET 239..>269 CDD:394802 11/27 (41%)
zf-MYND 296..335 CDD:460312 12/44 (27%)
SET_SMYD4 404..602 CDD:380934 42/200 (21%)
TPR_12 660..726 CDD:315987 13/46 (28%)
TPR_12 698..771 CDD:315987 4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

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