DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment porin and vdac-1

DIOPT Version :9

Sequence 1:	NP_001033899.1	Gene:	porin / 34500	FlyBaseID:	FBgn0004363	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_501211.1	Gene:	vdac-1 / 177524	WormBaseID:	WBGene00019900	Length:	283	Species:	Caenorhabditis elegans

Alignment Length:	286	Identity:	113/286 - (39%)
Similarity:	170/286 - (59%)	Gaps:	11/286 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPPSYSDLGKQARDIFSKGYNFGLWKLDLKTKTSSG--IEFNTAGHSNQESGKVFGSLETKYKV 63
            ||||:::||||.|:|:|:||||||..|:|..|:....  :||.:|...|..|||:.|:|:.|||:
Worm     1 MAPPTFADLGKSAKDLFNKGYNFGFLKIDSTTRAGDNKEVEFKSAASHNIGSGKLGGNLDVKYKI 65

  Fly    64 KDYGLTLTEKWNTDNTLFTEVAVQDQLLEGLKLSLEGNFAPQSGNKNGKFKVAYGHENVKADSDV 128
            ..||:||||||||:|.|.|.:.|.:|...|||::|:..:||.:|.::||.|:.:.....:..:||
Worm    66 PQYGITLTEKWNTENQLGTVIEVNEQFGRGLKVTLDSLYAPHAGKRSGKVKLDWALPTARVTADV 130

  Fly   129 NIDLKGPLINASAVLGYQGWLAGYQTAFDTQQSKLTTNNFALGYTTKDFVLHTAVNDGQEFSGSI 193
            .: ...|:|||:.|....|||.|....||:..:||...:.|.|::|..:.||:.|.:..:|..|:
Worm   131 GV-TSAPVINAAGVFSRDGWLIGAAATFDSSSNKLAATSLAFGHSTPQYTLHSFVINSTDFGASL 194

  Fly   194 FQRTSDKLDVGVQLSWASGTSNTKFAIGAKYQLDDDASVRAKVNNASQVGLGYQQKLRDGVTLTL 258
            :.:.:..::||.||.|..|.:...:|:..||....|.:||||||::|||.:.....|...:.|||
Worm   195 YHKVASNVEVGTQLGWKVGGNGADYALATKYAPSRDLTVRAKVNSSSQVAVAATHSLSPALKLTL 259

  Fly   259 STLVDGKNFNAG---GHKIGVGLELE 281
            ||     .||..   .||.|:|||.:
Worm   260 ST-----QFNLAANDAHKFGLGLEFD 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
porin	NP_001033899.1	Porin3_VDAC	3..281	CDD:132767	111/282 (39%)
vdac-1	NP_501211.1	Porin3_VDAC	3..280	CDD:132767	111/282 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162457
Domainoid	1	1.000	216	1.000	Domainoid score	I1563
eggNOG	1	0.900	-	-		E1_KOG3126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37765
Inparanoid	1	1.050	225	1.000	Inparanoid score	I2240
Isobase	1	0.950	-	0	Normalized mean entropy	S1329
OMA	1	1.010	-	-		QHG51941
OrthoDB	1	1.010	-	-		D550640at33208
OrthoFinder	1	1.000	-	-		FOG0001091
OrthoInspector	1	1.000	-	-		otm14109
orthoMCL	1	0.900	-	-		OOG6_101484
Panther	1	1.100	-	-	LDO	PTHR11743
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1638
SonicParanoid	1	1.000	-	-		X928
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790